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Ercc1 Ercc1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36654, updated on 2-Nov-2024

Summary

Official Symbol
Ercc1provided by FlyBase
Official Full Name
Ercc1provided by FlyBase
Primary source
FLYBASE:FBgn0028434
Locus tag
Dmel_CG10215
See related
AllianceGenome:FB:FBgn0028434
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10215; Dmel\CG10215; ercc1; ERCC1
Summary
Enables protein heterodimerization activity. Involved in nucleotide-excision repair and resolution of meiotic recombination intermediates. Part of protein-containing complex. Human ortholog(s) of this gene implicated in several diseases, including azoospermia; carcinoma (multiple); cerebrooculofacioskeletal syndrome 4; gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human ERCC1 (ERCC excision repair 1, endonuclease non-catalytic subunit). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See Ercc1 in Genome Data Viewer
Location:
51C5-51C5; 2-72 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14852941..14853948)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10740446..10741453)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Structural maintenance of chromosomes 2 Neighboring gene Ciao1 Neighboring gene Hermansky-Pudlak Syndrome 1 Neighboring gene uncharacterized protein Neighboring gene U3 small nuclear riboprotein factor 55K

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables damaged DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables damaged DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in UV-damage excision repair IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nucleotide-excision repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nucleotide-excision repair ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in resolution of meiotic recombination intermediates IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of ERCC4-ERCC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of nucleotide-excision repair factor 1 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Ercc1
Names
CG10215-PA
Ercc1-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    14852941..14853948
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058120.3NP_477468.1  Ercc1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477468.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KMG7, Q95S37
    Related
    FBpp0086578
    Conserved Domains (4) summary
    COG5241
    Location:1257
    RAD10; Nucleotide excision repair endonuclease NEF1, RAD10 subunit [DNA replication, recombination, and repair]
    pfam03834
    Location:62176
    Rad10; Binding domain of DNA repair protein Ercc1 (rad10/Swi10)
    pfam07590
    Location:2670
    DUF1556; Protein of unknown function (DUF1556)
    pfam14520
    Location:202254
    HHH_5; Helix-hairpin-helix domain