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SMC2 Structural maintenance of chromosomes 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36653, updated on 30-Jun-2026
Official Symbol
SMC2provided by FlyBase
Official Full Name
Structural maintenance of chromosomes 2provided by FlyBase
Primary source
FLYBASE:FBgn0027783
Locus tag
Dmel_CG10212
See related
AllianceGenome:FB:FBgn0027783
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AAF58197; CG10212; Dmel\CG10212; DmSMC2; dSMC2; smc-2; Smc2
Summary
Predicted to enable chromatin binding activity and protein heterodimerization activity. Predicted to contribute to ATP hydrolysis activity. Involved in chromosome condensation and regulation of stem cell differentiation. Located in chromatin and cytoplasm. Part of condensin complex. Colocalizes with condensed chromosome. Is expressed in several structures, including CNS glial cell; antennal primordium; embryonic/larval midgut primordium; ganglia; and head epidermis primordium. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Orthologous to human SMC2 (structural maintenance of chromosomes 2). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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See SMC2 in Genome Data Viewer
Location:
51C5-51C5; 2-72 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14848621..14852653, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10736126..10740158, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Na[+]-dependent inorganic phosphate cotransporter Neighboring gene uncharacterized protein Neighboring gene Ercc1 Neighboring gene Ciao1 Neighboring gene Hermansky-Pudlak Syndrome 1 Neighboring gene uncharacterized protein

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Condensin-mediated restriction of retrotransposable elements facilitates brain development in Drosophila melanogaster. Crawford BI, et al. Nat Commun, 2024 Mar 28. PMID 38548759, Free PMC Article
  2. Drosophila casein kinase I alpha regulates homolog pairing and genome organization by modulating condensin II subunit Cap-H2 levels. Nguyen HQ, et al. PLoS Genet, 2015. PMID 25723539, Free PMC Article
  3. Condensin I is required for faithful meiosis in Drosophila males. Kleinschnitz K, et al. Chromosoma, 2020 Jun. PMID 32314039, Free PMC Article
  4. Drosophila ERCC1 is required for a subset of MEI-9-dependent meiotic crossovers. Radford SJ, et al. Genetics, 2005 Aug. PMID 15944364, Free PMC Article
  5. Condensin II drives large-scale folding and spatial partitioning of interphase chromosomes in Drosophila nuclei. Rosin LF, et al. PLoS Genet, 2018 Jul. PMID 30001329, Free PMC Article

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Preferred Names
structural maintenance of chromosomes 2
Names
CG10212-PA
SMC2-PA

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    14848621..14852653 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137151.4 → NP_610995.1  structural maintenance of chromosomes 2

    See identical proteins and their annotated locations for NP_610995.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z9V8, Q4QQB8, Q7KK96
    Related
    FBpp0086591
    Conserved Domains (5) summary
    cl14654
    Location:690 → 933
    V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
    cd03273
    Location:1 → 170
    ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
    smart00968
    Location:520 → 637
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:1 → 1168
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl21455
    Location:1073 → 1167
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KK96 Q7KK96
Q8T0F9 Q8T0F9

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