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Tnfrsf14 TNF receptor superfamily member 14 [ Rattus norvegicus (Norway rat) ]

Gene ID: 366518, updated on 6-Jul-2026
Official Symbol
Tnfrsf14provided by RGD
Official Full Name
TNF receptor superfamily member 14provided by RGD
Primary source
RGD:1310115
See related
Ensembl:ENSRNOG00000013820 AllianceGenome:RGD:1310115
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cytokine binding activity; receptor ligand activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including defense response to bacterium; negative regulation of adaptive immune memory response; and regulation of T cell activation. Predicted to act upstream of or within negative regulation of CD4-positive, alpha-beta T cell proliferation and positive regulation of peptidyl-tyrosine phosphorylation. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Biomarker of myocardial infarction. Orthologous to human TNFRSF14 (TNF receptor superfamily member 14). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Spleen (RPKM 200.7), Thymus (RPKM 90.8) and 2 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See Tnfrsf14 in Genome Data Viewer
Location:
5q36
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (170768413..170776749, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (165486069..165494421, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene membrane metallo-endopeptidase-like 1 Neighboring gene peroxiredoxin like 2B Neighboring gene hes family bHLH transcription factor 5 Neighboring gene pantothenate kinase 4 Neighboring gene phospholipase C, eta 2

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Increased expression of LIGHT/TNFSF14 and its receptors in experimental and clinical heart failure. Dahl CP, et al. Eur J Heart Fail, 2008 Apr. PMID 18353719
  2. Tumor necrosis factor receptor superfamily 14 is involved in atherogenesis by inducing proinflammatory cytokines and matrix metalloproteinases. Lee WH, et al. Arterioscler Thromb Vasc Biol, 2001 Dec. PMID 11742877
  3. LIGHT/TNFSF14 enhances adipose tissue inflammatory responses through its interaction with HVEM. Kim HM, et al. FEBS Lett, 2011 Feb 4. PMID 21236258
  4. CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator. Cai G, et al. Nat Immunol, 2008 Feb. PMID 18193050
  5. LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response. Tamada K, et al. J Immunol, 2000 Apr 15. PMID 10754304

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Clone Names

  • MGC108903

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytokine binding ISO
Inferred from Sequence Orthology
more info
  
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in T cell costimulation ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within defense response to Gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of adaptive immune memory response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of alpha-beta T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of T cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cytokine production involved in immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of T cell tolerance induction to tumor cell ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of plasma membrane protein complex ISO
Inferred from Sequence Orthology
more info
  
part_of tumor necrosis factor receptor superfamily complex ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
tumor necrosis factor receptor superfamily member 14
Names
tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001015034.1 → NP_001015034.1  tumor necrosis factor receptor superfamily member 14 precursor

    See identical proteins and their annotated locations for NP_001015034.1

    Status: VALIDATED

    Source sequence(s)
    BC091202
    UniProtKB/TrEMBL
    Q5BK53
    Related
    ENSRNOP00000018492.7, ENSRNOT00000018494.7
    Conserved Domains (3) summary
    cd00185
    Location:136 → 199
    TNFRSF; CRD2 [structural motif]
    cd10582
    Location:40 → 140
    TNFRSF14; Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM)
    cl22855
    Location:97 → 204
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    170768413..170776749 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063288145.1 → XP_063144215.1  tumor necrosis factor receptor superfamily member 14 isoform X6

  2. XM_039110510.2 → XP_038966438.1  tumor necrosis factor receptor superfamily member 14 isoform X7

    Conserved Domains (2) summary
    cd00185
    Location:96 → 155
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
    cl22855
    Location:34 → 102
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

  3. XM_063288148.1 → XP_063144218.1  tumor necrosis factor receptor superfamily member 14 isoform X10

  4. XM_063288147.1 → XP_063144217.1  tumor necrosis factor receptor superfamily member 14 isoform X9

  5. XM_006239587.5 → XP_006239649.1  tumor necrosis factor receptor superfamily member 14 isoform X5

    Conserved Domains (3) summary
    cd00185
    Location:148 → 211
    TNFRSF; CRD2 [structural motif]
    cd10582
    Location:52 → 152
    TNFRSF14; Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM)
    cl22855
    Location:109 → 216
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

  6. XM_039110509.2 → XP_038966437.1  tumor necrosis factor receptor superfamily member 14 isoform X2

    Conserved Domains (3) summary
    cd00185
    Location:109 → 145
    TNFRSF; CRD1 [structural motif]
    cd10582
    Location:52 → 152
    TNFRSF14; Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM)
    cl22855
    Location:109 → 216
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

  7. XM_039110507.2 → XP_038966435.1  tumor necrosis factor receptor superfamily member 14 isoform X1

    Conserved Domains (3) summary
    cd00185
    Location:109 → 145
    TNFRSF; CRD1 [structural motif]
    cd10582
    Location:52 → 152
    TNFRSF14; Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM)
    cl22855
    Location:109 → 216
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

  8. XM_006239586.5 → XP_006239648.1  tumor necrosis factor receptor superfamily member 14 isoform X4

    See identical proteins and their annotated locations for XP_006239648.1

    UniProtKB/TrEMBL
    F7F4X8
    Conserved Domains (3) summary
    cd00185
    Location:148 → 211
    TNFRSF; CRD2 [structural motif]
    cd10582
    Location:52 → 152
    TNFRSF14; Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM)
    cl22855
    Location:109 → 216
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

  9. XM_063288146.1 → XP_063144216.1  tumor necrosis factor receptor superfamily member 14 isoform X6

  10. XM_039110508.2 → XP_038966436.1  tumor necrosis factor receptor superfamily member 14 isoform X1

    Conserved Domains (3) summary
    cd00185
    Location:109 → 145
    TNFRSF; CRD1 [structural motif]
    cd10582
    Location:52 → 152
    TNFRSF14; Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM)
    cl22855
    Location:109 → 216
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

  11. XM_039110511.2 → XP_038966439.1  tumor necrosis factor receptor superfamily member 14 isoform X8

    Conserved Domains (2) summary
    cd00185
    Location:72 → 131
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
    cl22855
    Location:4 → 70
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

  12. XM_063288144.1 → XP_063144214.1  tumor necrosis factor receptor superfamily member 14 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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