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IRF7 interferon regulatory factor 7 [ Homo sapiens (human) ]

Gene ID: 3665, updated on 9-Jun-2020

Summary

Official Symbol
IRF7provided by HGNC
Official Full Name
interferon regulatory factor 7provided by HGNC
Primary source
HGNC:HGNC:6122
See related
Ensembl:ENSG00000185507 MIM:605047
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IMD39; IRF-7; IRF7A; IRF7B; IRF7C; IRF7H; IRF-7H
Summary
IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. [provided by RefSeq, Jul 2008]
Expression
Broad expression in spleen (RPKM 16.7), lymph node (RPKM 8.9) and 24 other tissues See more
Orthologs

Genomic context

See IRF7 in Genome Data Viewer
Location:
11p15.5
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (612555..615999, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (612555..615999, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC143666 Neighboring gene PHD and ring finger domains 1 Neighboring gene cadherin related family member 5 Neighboring gene secretin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Immunodeficiency 39
MedGen: C4225358 OMIM: 616345 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat The interaction of HIV-1 Tat with cellular transcription factors CDK9 and Sp1 is required for Tat activation of MAP2K3-, MAP2K6-, and IRF7-mediated luciferase transcription PubMed
tat MAP2K6 and IRF7 induce HIV-1 Tat-mediated cellular gene modulation through the p38 MAPK/STAT1 pathway in immature dendritic cells and in monocyte-derived macrophages PubMed
tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including IFN regulatory factor 7A (IRF7), in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed
tat SiRNA-mediated inhibition of IRF7 reduces HIV-1 Tat-induced modulation of interferon (IFN)-stimulated genes in immature dendritic cells and in monocyte-derived macrophages PubMed
tat HIV-1 Tat-mediated downregulation of TRAF3 increases levels of phosphorylation of IRF3 and IRF7 in human microglial cells PubMed
Vpr vpr HIV-1 Vpr upregulates the expression of interferon regulatory factor 7 in human monocyte-derived macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
MDA-5 signaling pathway TAS
Traceable Author Statement
more info
PubMed 
TRIF-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
cellular response to DNA damage stimulus TAS
Traceable Author Statement
more info
PubMed 
defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
establishment of viral latency TAS
Traceable Author Statement
more info
PubMed 
immune system process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immunoglobulin mediated immune response IEA
Inferred from Electronic Annotation
more info
 
innate immune response TAS
Traceable Author Statement
more info
PubMed 
interferon-alpha production ISS
Inferred from Sequence or Structural Similarity
more info
 
interferon-beta production ISS
Inferred from Sequence or Structural Similarity
more info
 
interferon-gamma-mediated signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of macrophage apoptotic process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
positive regulation of interferon-alpha production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interferon-alpha production TAS
Traceable Author Statement
more info
PubMed 
positive regulation of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interferon-beta production TAS
Traceable Author Statement
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of type I interferon production TAS
Traceable Author Statement
more info
 
positive regulation of type I interferon-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of MyD88-dependent toll-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of MyD88-independent toll-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of adaptive immune response IDA
Inferred from Direct Assay
more info
PubMed 
regulation of immune response TAS
Traceable Author Statement
more info
PubMed 
regulation of monocyte differentiation TAS
Traceable Author Statement
more info
PubMed 
regulation of type I interferon production TAS
Traceable Author Statement
more info
PubMed 
response to virus TAS
Traceable Author Statement
more info
PubMed 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
type I interferon biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
type I interferon signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IGI
Inferred from Genetic Interaction
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endosome membrane TAS
Traceable Author Statement
more info
 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
interferon regulatory factor 7
Names
interferon regulatory factor 7G isoform
interferon regulatory factor-7H

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029106.1 RefSeqGene

    Range
    5050..8445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1313

mRNA and Protein(s)

  1. NM_001572.5NP_001563.2  interferon regulatory factor 7 isoform a

    See identical proteins and their annotated locations for NP_001563.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a) has an alternate exon structure in the 5' coding region, resulting in the use of an alternate start codon compared to variant d. The resulting isoform (a) is shorter and has a distinct N-terminus compared to isoform d.
    Source sequence(s)
    AF076494, BM849172, U53830, U53831, U73036
    Consensus CDS
    CCDS7703.1
    UniProtKB/Swiss-Prot
    Q92985
    Related
    ENSP00000434009.2, ENST00000525445.6
    Conserved Domains (2) summary
    pfam00605
    Location:13124
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:289466
    IRF-3; Interferon-regulatory factor 3
  2. NM_004029.4NP_004020.1  interferon regulatory factor 7 isoform b

    See identical proteins and their annotated locations for NP_004020.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b) has an alternate exon structure in the 5' coding region and lacks an alternate in-frame exon, compared to variant d. The resulting isoform (b) is shorter and has a distinct N-terminus compared to isoform d.
    Source sequence(s)
    AF076494, BM849172, U53831
    Consensus CDS
    CCDS7704.1
    UniProtKB/Swiss-Prot
    Q92985
    UniProtKB/TrEMBL
    A0A024RCA2
    Related
    ENSP00000331803.9, ENST00000348655.11
    Conserved Domains (2) summary
    pfam00605
    Location:13124
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:260437
    IRF-3; Interferon-regulatory factor 3
  3. NM_004031.4NP_004022.2  interferon regulatory factor 7 isoform d

    See identical proteins and their annotated locations for NP_004022.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (d) encodes the longest isoform (d).
    Source sequence(s)
    AF076494, BM849172, U53830, U53831, U73036
    Consensus CDS
    CCDS7705.1
    UniProtKB/Swiss-Prot
    Q92985
    Related
    ENSP00000329411.5, ENST00000330243.9
    Conserved Domains (2) summary
    pfam00605
    Location:26137
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:302479
    IRF-3; Interferon-regulatory factor 3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    612555..615999 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520066.3XP_011518368.1  interferon regulatory factor 7 isoform X3

    See identical proteins and their annotated locations for XP_011518368.1

    Conserved Domains (2) summary
    pfam00605
    Location:13124
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:288465
    IRF-3; Interferon-regulatory factor 3
  2. XM_005252907.3XP_005252964.1  interferon regulatory factor 7 isoform X2

    See identical proteins and their annotated locations for XP_005252964.1

    Conserved Domains (2) summary
    pfam00605
    Location:26137
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:301478
    IRF-3; Interferon-regulatory factor 3
  3. XM_005252909.3XP_005252966.1  interferon regulatory factor 7 isoform X4

    See identical proteins and their annotated locations for XP_005252966.1

    UniProtKB/TrEMBL
    M9RSF4
    Related
    ENSP00000380700.2, ENST00000397570.5
    Conserved Domains (2) summary
    pfam00605
    Location:26137
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:273450
    IRF-3; Interferon-regulatory factor 3
  4. XM_017017674.1XP_016873163.1  interferon regulatory factor 7 isoform X5

    UniProtKB/Swiss-Prot
    Q92985
    UniProtKB/TrEMBL
    B4E1B1
    Conserved Domains (1) summary
    pfam10401
    Location:1173
    IRF-3; Interferon-regulatory factor 3

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187586.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    142448..145849 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_004030.1: Suppressed sequence

    Description
    NM_004030.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
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