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Sh2d5 SH2 domain containing 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 366489, updated on 3-Jun-2026
Official Symbol
Sh2d5provided by RGD
Official Full Name
SH2 domain containing 5provided by RGD
Primary source
RGD:1305952
See related
Ensembl:ENSRNOG00000014909 AllianceGenome:RGD:1305952
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305952
Summary
Predicted to be active in postsynaptic density. Orthologous to human SH2D5 (SH2 domain containing 5). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Brain (RPKM 45.7), Spleen (RPKM 6.1) and 3 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See Sh2d5 in Genome Data Viewer
Location:
5q36
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (155753087..155763936)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (150469738..150480615)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (156615889..156624962)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene macrophage migration inhibitory factor, pseudogene 5 Neighboring gene heterochromatin protein 1, binding protein 3 Neighboring gene uncharacterized LOC134487021 Neighboring gene kinesin family member 17 Neighboring gene dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Src homology 2 domain containing protein 5 (SH2D5) binds the breakpoint cluster region protein, BCR, and regulates levels of Rac1-GTP. Gray EJ, et al. J Biol Chem, 2014 Dec 19. PMID 25331951, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that Src homology 2 domain containing protein 5 (SH2D5) controls neuronal morphology via breakpoint cluster region protein BCR and Rac1 GTP binding protein.
    Title: Src homology 2 domain containing protein 5 (SH2D5) binds the breakpoint cluster region protein, BCR, and regulates levels of Rac1-GTP.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
SH2 domain-containing protein 5

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001431207.1 → NP_001418136.1  SH2 domain-containing protein 5 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A096MJ64, A0A096MJD8, A6ITG7, D3ZWT6

  2. NM_001431208.1 → NP_001418137.1  SH2 domain-containing protein 5 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A096MJ64, A0A096MJD8, A6ITG7, D3ZWT6

  3. NM_001431209.1 → NP_001418138.1  SH2 domain-containing protein 5 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A096MJ64, A0A096MJD8, A6ITG7, D3ZWT6

  4. NM_001431210.1 → NP_001418139.1  SH2 domain-containing protein 5 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A096MJD8, D3ZWT6

  5. NM_001431211.1 → NP_001418140.1  SH2 domain-containing protein 5 isoform c

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

  6. NM_001431212.1 → NP_001418141.1  SH2 domain-containing protein 5 isoform c

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

  7. NM_001431213.1 → NP_001418142.1  SH2 domain-containing protein 5 isoform c

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    155753087..155763936
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039111317.2 → XP_038967245.1  

    Conserved Domains (2) summary
    cd00173
    Location:302 → 378
    SH2; Src homology 2 (SH2) domain
    cd13157
    Location:23 → 150
    PTB_tensin-related; Tensin-related Phosphotyrosine-binding (PTB) domain

  2. XM_006239286.5 → XP_006239348.1  

    Conserved Domains (2) summary
    cd00173
    Location:218 → 294
    SH2; Src homology 2 (SH2) domain
    cl17171
    Location:1 → 66
    PH-like; Pleckstrin homology-like domain

  3. XM_006239283.4 → XP_006239345.1  

    Related
    ENSRNOP00000068008.3, ENSRNOT00000076439.4
    Conserved Domains (2) summary
    cd00173
    Location:302 → 378
    SH2; Src homology 2 (SH2) domain
    cd13157
    Location:23 → 150
    PTB_tensin-related; Tensin-related Phosphotyrosine-binding (PTB) domain

  4. XM_063288638.1 → XP_063144708.1  

  5. XM_063288637.1 → XP_063144707.1  

  6. XM_063288639.1 → XP_063144709.1  

  7. XM_039111316.2 → XP_038967244.1  SH2 domain-containing protein 5 isoform X1

    UniProtKB/TrEMBL
    A0A096MJ64, A0A096MJD8, A6ITG7, D3ZWT6
    Conserved Domains (2) summary
    cd00173
    Location:302 → 378
    SH2; Src homology 2 (SH2) domain
    cd13157
    Location:23 → 150
    PTB_tensin-related; Tensin-related Phosphotyrosine-binding (PTB) domain

  8. XM_039111315.2 → XP_038967243.1  SH2 domain-containing protein 5 isoform X1

    UniProtKB/TrEMBL
    A0A096MJ64, A0A096MJD8, A6ITG7, D3ZWT6
    Conserved Domains (2) summary
    cd00173
    Location:302 → 378
    SH2; Src homology 2 (SH2) domain
    cd13157
    Location:23 → 150
    PTB_tensin-related; Tensin-related Phosphotyrosine-binding (PTB) domain
Nucleotide Protein Strain
Heading Accession and Version

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