U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mpl MPL proto-oncogene, thrombopoietin receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 366455, updated on 30-Jul-2025
Official Symbol
Mplprovided by RGD
Official Full Name
MPL proto-oncogene, thrombopoietin receptorprovided by RGD
Primary source
RGD:1311069
See related
Ensembl:ENSRNOG00000028377 AllianceGenome:RGD:1311069
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable thrombopoietin receptor activity. Involved in several processes, including basophil homeostasis; eosinophil homeostasis; and monocyte homeostasis. Located in cell surface and neuronal cell body. Used to study myelofibrosis. Biomarker of thrombocytopenia. Human ortholog(s) of this gene implicated in congenital amegakaryocytic thrombocytopenia 1; essential thrombocythemia; myelofibrosis; thrombocytopenia; and thrombocytosis. Orthologous to human MPL (MPL proto-oncogene, thrombopoietin receptor). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Spleen (RPKM 10.6), Testes (RPKM 2.4) and 3 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table
See Mpl in Genome Data Viewer
Location:
5q36
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (137259288..137281540, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (131973895..131987472, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (137268412..137282032, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692460 Neighboring gene cell division cycle 20 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC102554074 Neighboring gene tyrosine kinase with immunoglobulin-like and EGF-like domains 1 Neighboring gene transmembrane protein 258 like 2

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Repeated Lusutrombopag Treatment for Thrombocytopenia in Patients with Chronic Liver Disease. Sano Y, et al. Digestion, 2021. PMID 32841939
  2. Pharmacokinetics and hematological effects of the PEGylated thrombopoietin peptide mimetic GW395058 in rats and monkeys after intravenous or subcutaneous administration. de Serres M, et al. Stem Cells, 1999. PMID 10606160
  3. Molecular detection of c-mpl thrombopoietin receptor gene expression in chronic myeloproliferative disorders. Duensing S, et al. Mol Pathol, 1999 Jun. PMID 10621836, Free PMC Article
  4. Effects of thrombopoietin on growth of hepatocellular carcinoma: Is thrombopoietin therapy for liver disease safe or not? Nozaki R, et al. Hepatol Res, 2013 Jun. PMID 23157389
  5. The platelet thrombopoietin receptor number and function are markedly decreased in patients with essential thrombocythaemia. Li J, et al. Br J Haematol, 2000 Dec. PMID 11122159

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytokine receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables thrombopoietin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thrombopoietin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables thrombopoietin receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in basophil homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within definitive hemopoiesis ISO
Inferred from Sequence Orthology
more info
  
involved_in eosinophil homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within homeostasis of number of cells ISO
Inferred from Sequence Orthology
more info
  
involved_in monocyte homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in neutrophil homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in platelet formation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within platelet formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of lymphocyte proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of platelet formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of stem cell division ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of stem cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in thrombopoietin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within thrombopoietin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in thrombopoietin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within thrombopoietin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in thrombopoietin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
thrombopoietin receptor
Names
myeloproliferative leukemia virus oncogene

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419844.1 → NP_001406773.1  thrombopoietin receptor precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A1W2Q6N1, A6JZI6, A6JZI7
    Related
    ENSRNOP00000076315.1, ENSRNOT00000093301.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    137259288..137281540 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063288117.1 → XP_063144187.1  thrombopoietin receptor isoform X7

    UniProtKB/TrEMBL
    A6JZI6

  2. XM_017593806.3 → XP_017449295.1  thrombopoietin receptor isoform X3

  3. XM_017593805.3 → XP_017449294.1  thrombopoietin receptor isoform X2

    UniProtKB/TrEMBL
    A6JZI6
    Conserved Domains (2) summary
    cd00063
    Location:437 → 526
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:121 → 219
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  4. XM_063288118.1 → XP_063144188.1  thrombopoietin receptor isoform X8

  5. XM_017593804.3 → XP_017449293.1  thrombopoietin receptor isoform X1

    UniProtKB/TrEMBL
    A6JZI6
    Conserved Domains (2) summary
    cd00063
    Location:497 → 586
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:121 → 219
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  6. XM_063288116.1 → XP_063144186.1  thrombopoietin receptor isoform X6

    UniProtKB/TrEMBL
    A6JZI6

  7. XM_006238749.5 → XP_006238811.1  thrombopoietin receptor isoform X5

    See identical proteins and their annotated locations for XP_006238811.1

    UniProtKB/TrEMBL
    A6JZI5, A6JZI6
    Conserved Domains (2) summary
    cd00063
    Location:346 → 435
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:25 → 128
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  8. XM_039111192.2 → XP_038967120.1  thrombopoietin receptor isoform X4

    Conserved Domains (2) summary
    cd00063
    Location:497 → 586
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:121 → 219
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RNA

  1. XR_005504959.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools