Crls1 cardiolipin synthase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Crls1provided by RGD
Official Full Name: cardiolipin synthase 1provided by RGD
Primary source: RGD:1311037
See related: Ensembl:ENSRNOG00000021273 AllianceGenome:RGD:1311037
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1311037
Summary: Enables cardiolipin synthase activity. Involved in response to phosphatidylethanolamine and response to thyroxine. Located in mitochondrial membrane. Orthologous to human CRLS1 (cardiolipin synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 247.2), Kidney (RPKM 226.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q36

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (140572680..140591543)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (120119822..120138674)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (125503638..125522460)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knock-down of cardiolipin synthase affected the cellular CL content in the presence of linoleic acid (LA) in the culture medium.
Title: Effects of siRNA-dependent knock-down of cardiolipin synthase and tafazzin on mitochondria and proliferation of glioma cells.
CL has roles in in neuronal signaling, mitochondrial bioenergetics, and apoptosis
Title: Shotgun lipidomics reveals the temporally dependent, highly diversified cardiolipin profile in the mammalian brain: temporally coordinated postnatal diversification of cardiolipin molecular species with neuronal remodeling.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cardiolipin synthase (CMP-forming)	IBA Inferred from Biological aspect of Ancestor more info
enables cardiolipin synthase (CMP-forming)	IDA Inferred from Direct Assay more info	PubMed
enables cardiolipin synthase (CMP-forming)	ISO Inferred from Sequence Orthology more info
enables cardiolipin synthase (CMP-forming)	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cardiolipin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiolipin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cardiolipin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to phosphatidylethanolamine	IDA Inferred from Direct Assay more info	PubMed
involved_in response to thyroxine	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cardiolipin synthase (CMP-forming)

Names: CLS; cardiolipin synthetase

NP_001014280.1

EC 2.7.8.41

XP_006235140.1

EC 2.7.8.41

XP_006235141.1

EC 2.7.8.41

XP_006235142.1

EC 2.7.8.41

XP_063140355.1

EC 2.7.8.41

XP_063140356.1

EC 2.7.8.41

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014258.1 → NP_001014280.1 cardiolipin synthase (CMP-forming)

See identical proteins and their annotated locations for NP_001014280.1

Status: PROVISIONAL

Source sequence(s)

BC085849

UniProtKB/Swiss-Prot

Q5U2V5

UniProtKB/TrEMBL

A6HQH5

Related

ENSRNOP00000028900.5, ENSRNOT00000028900.7

Conserved Domains (1) summary

COG0558
Location:107 → 297

PgsA; Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]