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Spi1 Spi-1 proto-oncogene [ Rattus norvegicus (Norway rat) ]

Gene ID: 366126, updated on 30-Sep-2021

Summary

Symbol
Spi1provided by RGD
Full Name
Spi-1 proto-oncogeneprovided by RGD
Primary source
RGD:1359607
See related
EnsemblRapid:ENSRNOG00000012172
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pu.1; Sfpi1
Expression
Biased expression in Spleen (RPKM 127.3), Lung (RPKM 63.9) and 8 other tissues See more
Orthologs
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Genomic context

See Spi1 in Genome Data Viewer
Location:
3q24
Exon count:
7
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (77059744..77093730)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (79918127..79937708)

Chromosome 3 - NC_051338.1Genomic Context describing neighboring genes Neighboring gene proteasome 26S subunit, ATPase 3 Neighboring gene solute carrier family 39 member 13 Neighboring gene uncharacterized LOC120101909 Neighboring gene myosin binding protein C3 Neighboring gene MAP-kinase activating death domain

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription repressor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables NFAT protein binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables STAT family protein binding IEA
Inferred from Electronic Annotation
more info
 
enables STAT family protein binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein sequestering activity ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_positive_effect TRAIL-activated apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within anatomical structure regression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic process involved in blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in defense response to tumor cell ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within endothelial to hematopoietic transition ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in follicular B cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in germinal center B cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within granulocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in histone H3 acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in hypermethylation of CpG island ISO
Inferred from Sequence Orthology
more info
 
involved_in immature B cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-6-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lymphocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lymphoid progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within myeloid dendritic cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within myeloid leukocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in myeloid leukocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of MHC class II biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of NIK/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of adipose tissue development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression, epigenetic ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of histone H4 acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neutrophil degranulation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein localization to chromatin ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in oncogene-induced cell senescence ISO
Inferred from Sequence Orthology
more info
 
involved_in pericyte cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of antifungal innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of microglial cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of myeloid dendritic cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of pri-miRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in pro-T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of histone H3-K27 acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of myeloid progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within somatic stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within vasculature development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transcription factor PU.1
Names
SFFV proviral integration 1
hematopoietic transcription factor PU.1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
spleen focus forming virus proviral integration oncogene spi1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005892.2NP_001005892.1  transcription factor PU.1

    See identical proteins and their annotated locations for NP_001005892.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091185
    UniProtKB/Swiss-Prot
    Q6BDS1
    Related
    ENSRNOP00000016306.5, ENSRNOT00000016306.7
    Conserved Domains (1) summary
    pfam00178
    Location:172253
    Ets; Ets-domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051338.1 Reference mRatBN7.2 Primary Assembly

    Range
    77059744..77093730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039105594.1XP_038961522.1  transcription factor PU.1 isoform X3

    Conserved Domains (1) summary
    pfam00178
    Location:85166
    Ets; Ets-domain
  2. XM_039105596.1XP_038961524.1  transcription factor PU.1 isoform X3

    Conserved Domains (1) summary
    pfam00178
    Location:85166
    Ets; Ets-domain
  3. XM_006234532.4XP_006234594.1  transcription factor PU.1 isoform X2

    Related
    ENSRNOP00000077751.1, ENSRNOT00000114733.1
    Conserved Domains (1) summary
    pfam00178
    Location:173254
    Ets; Ets-domain
  4. XM_039105593.1XP_038961521.1  transcription factor PU.1 isoform X1

    Conserved Domains (1) summary
    pfam00178
    Location:176257
    Ets; Ets-domain
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