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Spi1 Spi-1 proto-oncogene [ Rattus norvegicus (Norway rat) ]

Gene ID: 366126, updated on 18-Nov-2018

Summary

Official Symbol
Spi1provided by RGD
Official Full Name
Spi-1 proto-oncogeneprovided by RGD
Primary source
RGD:1359607
See related
Ensembl:ENSRNOG00000012172
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pu.1; Sfpi1
Expression
Biased expression in Spleen (RPKM 127.3), Lung (RPKM 63.9) and 8 other tissues See more
Orthologs

Genomic context

See Spi1 in Genome Data Viewer
Location:
3q24
Exon count:
5
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (79918127..79937708)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (86627684..86646468)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene solute carrier family 39 member 13 Neighboring gene uncharacterized LOC103691845 Neighboring gene uncharacterized LOC102555995 Neighboring gene myosin binding protein C, cardiac Neighboring gene MAP-kinase activating death domain

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Acute myeloid leukemia, organism-specific biosystem (from KEGG)
    Acute myeloid leukemia, organism-specific biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
  • Acute myeloid leukemia, conserved biosystem (from KEGG)
    Acute myeloid leukemia, conserved biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
  • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
    Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
  • Epstein-Barr virus infection, conserved biosystem (from KEGG)
    Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
  • HTLV-I infection, organism-specific biosystem (from KEGG)
    HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • HTLV-I infection, conserved biosystem (from KEGG)
    HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
  • Osteoclast differentiation, organism-specific biosystem (from KEGG)
    Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Osteoclast differentiation, conserved biosystem (from KEGG)
    Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
    Transcriptional misregulation in cancer, organism-specific biosystem
    Transcriptional misregulation in cancer
  • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
    Transcriptional misregulation in cancer, conserved biosystem
    Transcriptional misregulation in cancer
  • Type II interferon signaling (IFNG), organism-specific biosystem (from WikiPathways)
    Type II interferon signaling (IFNG), organism-specific biosystemAdapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several ...

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
DNA binding ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
NFAT protein binding IEA
Inferred from Electronic Annotation
more info
 
NFAT protein binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II distal enhancer sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II distal enhancer sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
anatomical structure regression IEA
Inferred from Electronic Annotation
more info
 
anatomical structure regression ISO
Inferred from Sequence Orthology
more info
 
apoptotic process involved in blood vessel morphogenesis IEA
Inferred from Electronic Annotation
more info
 
apoptotic process involved in blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
granulocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
granulocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
histone H3 acetylation IEA
Inferred from Electronic Annotation
more info
 
histone H3 acetylation ISO
Inferred from Sequence Orthology
more info
 
hypermethylation of CpG island IEA
Inferred from Electronic Annotation
more info
 
hypermethylation of CpG island ISO
Inferred from Sequence Orthology
more info
 
lymphocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
lymphocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
lymphoid progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
lymphoid progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
macrophage differentiation IEA
Inferred from Electronic Annotation
more info
 
macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
myeloid dendritic cell differentiation IEA
Inferred from Electronic Annotation
more info
 
myeloid dendritic cell differentiation ISO
Inferred from Sequence Orthology
more info
 
myeloid leukocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of MHC class II biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of MHC class II biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression, epigenetic IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gene expression, epigenetic ISO
Inferred from Sequence Orthology
more info
 
negative regulation of histone H4 acetylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of histone H4 acetylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of pri-miRNA transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of pri-miRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
pri-miRNA transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
pri-miRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
regulation of erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
somatic stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
somatic stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
vasculature development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
nuclear chromatin IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transcription factor PU.1
Names
SFFV proviral integration 1
hematopoietic transcription factor PU.1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
spleen focus forming virus proviral integration oncogene spi1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005892.2NP_001005892.1  transcription factor PU.1

    See identical proteins and their annotated locations for NP_001005892.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091185
    UniProtKB/Swiss-Prot
    Q6BDS1
    Related
    ENSRNOP00000016306.4, ENSRNOT00000016306.6
    Conserved Domains (1) summary
    smart00413
    Location:170258
    ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    79918127..79937708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234532.3XP_006234594.1  transcription factor PU.1 isoform X1

    Conserved Domains (1) summary
    smart00413
    Location:171259
    ETS; erythroblast transformation specific domain

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    76282068..76300680
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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