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IRF2 interferon regulatory factor 2 [ Homo sapiens (human) ]

Gene ID: 3660, updated on 8-Jul-2021

Summary

Official Symbol
IRF2provided by HGNC
Official Full Name
interferon regulatory factor 2provided by HGNC
Primary source
HGNC:HGNC:6117
See related
Ensembl:ENSG00000168310 MIM:147576
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IRF-2
Summary
IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in spleen (RPKM 28.3), lymph node (RPKM 28.2) and 25 other tissues See more
Orthologs
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Genomic context

See IRF2 in Genome Data Viewer
Location:
4q35.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (184382741..184474580, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (185308883..185395704, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986332 Neighboring gene long intergenic non-protein coding RNA 2363 Neighboring gene long intergenic non-protein coding RNA 2362 Neighboring gene long intergenic non-protein coding RNA 2427 Neighboring gene GAR1 ribonucleoprotein homolog (yeast) pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV/tuberculosis coinfection upregulates IRF2 expression in pleural fluid mononuclear cells (PFMC) isolated from antiretroviral-naive coinfected patients (relative to patients infected with only tuberculosis) PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef upregulates interferon regulatory factor 2 (IRF-2) in human T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686F0244

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
interferon regulatory factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002199.4NP_002190.2  interferon regulatory factor 2

    See identical proteins and their annotated locations for NP_002190.2

    Status: REVIEWED

    Source sequence(s)
    AA361545, BC015803, BP200998, BQ017798
    Consensus CDS
    CCDS3835.1
    UniProtKB/Swiss-Prot
    P14316
    Related
    ENSP00000377218.3, ENST00000393593.8
    Conserved Domains (1) summary
    pfam00605
    Location:7112
    IRF; Interferon regulatory factor transcription factor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    184382741..184474580 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024454039.1XP_024309807.1  interferon regulatory factor 2 isoform X3

    Conserved Domains (1) summary
    pfam00605
    Location:7112
    IRF; Interferon regulatory factor transcription factor
  2. XM_024454037.1XP_024309805.1  interferon regulatory factor 2 isoform X2

    Conserved Domains (1) summary
    pfam00605
    Location:7112
    IRF; Interferon regulatory factor transcription factor
  3. XM_024454038.1XP_024309806.1  interferon regulatory factor 2 isoform X2

    Conserved Domains (1) summary
    pfam00605
    Location:7112
    IRF; Interferon regulatory factor transcription factor
  4. XM_024454035.1XP_024309803.1  interferon regulatory factor 2 isoform X1

    Conserved Domains (1) summary
    pfam00605
    Location:7112
    IRF; Interferon regulatory factor transcription factor
  5. XM_024454034.1XP_024309802.1  interferon regulatory factor 2 isoform X1

    Conserved Domains (1) summary
    pfam00605
    Location:7112
    IRF; Interferon regulatory factor transcription factor
  6. XM_024454036.1XP_024309804.1  interferon regulatory factor 2 isoform X1

    Conserved Domains (1) summary
    pfam00605
    Location:7112
    IRF; Interferon regulatory factor transcription factor
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