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Arc2 Activity-regulated cytoskeleton associated protein 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36597, updated on 8-Apr-2026
Official Symbol
Arc2provided by FlyBase
Official Full Name
Activity-regulated cytoskeleton associated protein 2provided by FlyBase
Primary source
FLYBASE:FBgn0033928
Locus tag
Dmel_CG13941
See related
AllianceGenome:FB:FBgn0033928
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.456; BcDNA:SD11637; CG13941; dArc2; dARC2; Dmel\CG13941
Summary
Enables structural molecule activity. Located in extracellular vesicle and virus-like capsid. Orthologous to human ARC (activity regulated cytoskeleton associated protein). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See Arc2 in Genome Data Viewer
Location:
50F6-50F6; 2-70 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14361924..14362825)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10249429..10250330)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Activity-regulated cytoskeleton associated protein 1 Neighboring gene pseudo Neighboring gene Transcription factor B1 Neighboring gene uncharacterized protein

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Molecular physiology of Arc/Arg3.1: The oligomeric state hypothesis of synaptic plasticity. Eriksen MS, et al. Acta Physiol (Oxf), 2022 Nov. PMID 36073248, Free PMC Article
  2. Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc. Hallin EI, et al. PLoS One, 2021. PMID 33989344, Free PMC Article
  3. Intercellular Communication in the Nervous System Goes Viral. Hantak MP, et al. Trends Neurosci, 2021 Apr. PMID 33485691, Free PMC Article
  4. Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins. Erlendsson S, et al. Nat Neurosci, 2020 Feb. PMID 31907439, Free PMC Article
  5. dArc1 controls sugar reward valuation in Drosophila melanogaster. Bervoets S, et al. Curr Biol, 2025 Sep 8. PMID 40782803,

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc.
    Title: Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc.
  2. We report high-resolution structures of retrovirus-like capsids formed by Drosophila dArc1 and dArc2 that have surface spikes and putative internal RNA-binding domains
    Title: Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural molecule activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in virus-like capsid IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
Activity-regulated cytoskeleton associated protein 2
Names
Arc2-PA
CG13941-PA

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    14361924..14362825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137112.2 → NP_610956.1  Activity-regulated cytoskeleton associated protein 2

    See identical proteins and their annotated locations for NP_610956.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7JV70
    Related
    FBpp0086675
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JV70.1 Q7JV70

Gene LinkOut

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