U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Arc1 Activity-regulated cytoskeleton associated protein 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36595, updated on 8-Apr-2026
Official Symbol
Arc1provided by FlyBase
Official Full Name
Activity-regulated cytoskeleton associated protein 1provided by FlyBase
Primary source
FLYBASE:FBgn0033926
Locus tag
Dmel_CG12505
See related
AllianceGenome:FB:FBgn0033926
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0153538.31; anon-WO0153538.40; anon-WO0153538.41; anon-WO0153538.43; anon-WO0153538.45; Arc; arc1; CG12505; darc1; dArc1; dARC1; Dmel\CG12505
Summary
Enables mRNA binding activity and structural molecule activity. Involved in several processes, including behavioral response to starvation; mRNA transport; and vesicle-mediated intercellular transport. Located in several cellular components, including postsynapse of neuromuscular junction; sarcomere; and virus-like capsid. Is expressed in several structures, including adult antennal lobe; adult brain; adult head; ganglia; and pars intercerebralis. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See Arc1 in Genome Data Viewer
Location:
50F6-50F6; 2-70 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14357927..14360297, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10245432..10247802, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene Activity-regulated cytoskeleton associated protein 2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Tau-Induced Elevation of the Activity-Regulated Cytoskeleton Associated Protein Arc1 Causally Mediates Neurodegeneration in the Adult Drosophila Brain. Schulz L, et al. Neuroscience, 2023 May 10. PMID 35487302, Free PMC Article
  2. Turning gold into 'junk': transposable elements utilize central proteins of cellular networks. Abrusán G, et al. Nucleic Acids Res, 2013 Mar 1. PMID 23341038, Free PMC Article
  3. Molecular physiology of Arc/Arg3.1: The oligomeric state hypothesis of synaptic plasticity. Eriksen MS, et al. Acta Physiol (Oxf), 2022 Nov. PMID 36073248, Free PMC Article
  4. Drosophila Ortholog of Mammalian Immediate-Early Gene Npas4 is Specifically Responsive to Reversal Learning. Liu T, et al. Neurosci Bull, 2021 Jan. PMID 32856235, Free PMC Article
  5. Drosophila Arc1 is not required for male fertility or sperm competition success. Gordon K, et al. MicroPubl Biol, 2023. PMID 38089935, Free PMC Article

See all (116) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tau-Induced Elevation of the Activity-Regulated Cytoskeleton Associated Protein Arc1 Causally Mediates Neurodegeneration in the Adult Drosophila Brain.
    Title: Tau-Induced Elevation of the Activity-Regulated Cytoskeleton Associated Protein Arc1 Causally Mediates Neurodegeneration in the Adult Drosophila Brain.
  2. Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc.
    Title: Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc.
  3. Structure of Drosophila melanogaster ARC1 reveals a repurposed molecule with characteristics of retroviral Gag.
    Title: Structure of Drosophila melanogaster ARC1 reveals a repurposed molecule with characteristics of retroviral Gag.
  4. A Drosophila model of Pontocerebellar Hypoplasia reveals a critical role for the RNA exosome in neurons.
    Title: A Drosophila model of Pontocerebellar Hypoplasia reveals a critical role for the RNA exosome in neurons.
  5. We report high-resolution structures of retrovirus-like capsids formed by Drosophila dArc1 and dArc2 that have surface spikes and putative internal RNA-binding domains
    Title: Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins.
  6. Arc1 protein forms capsid-like structures that bind darc1 mRNA in neurons and is loaded into extracellular vesicles that are transferred from motorneurons to muscles.
    Title: Retrovirus-like Gag Protein Arc1 Binds RNA and Traffics across Synaptic Boutons.
  7. trr and G9a also have common direct targets, including the Drosophila ortholog of Arc (Arc1), a key regulator of synaptic plasticity. Our data highlight the clinical and molecular convergence between the KMT2 and EHMT protein families, which may contribute to a molecular network underlying a larger group of intellectual disability / autism spectrum disorder -related disorders.
    Title: Functional convergence of histone methyltransferases EHMT1 and KMT2C involved in intellectual disability and autism spectrum disorder.
  8. E347 neurons induce Arc1 in specific neighboring cells to prevent excess fat accumulation.
    Title: Coordination between Drosophila Arc1 and a specific population of brain neurons regulates organismal fat.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural molecule activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in behavioral response to starvation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell-cell signaling via exosome IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of neuronal synaptic plasticity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vesicle-mediated intercellular transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynapse of neuromuscular junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sarcomere IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in virus-like capsid IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
Activity-regulated cytoskeleton associated protein 1
Names
Arc1-PA
CG12505-PA
dArc1

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    14357927..14360297 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137111.3 → NP_610955.1  Activity-regulated cytoskeleton associated protein 1

    See identical proteins and their annotated locations for NP_610955.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7K1U0
    Related
    FBpp0086687
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K1U0.1 Q7K1U0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools