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cg combgap [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36571, updated on 6-Jul-2026
Official Symbol
cgprovided by FlyBase
Official Full Name
combgapprovided by FlyBase
Primary source
FLYBASE:FBgn0000289
Locus tag
Dmel_CG8367
See related
AllianceGenome:FB:FBgn0000289
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Cg; CG; CG8367; Combgap; Dmel\CG8367; l(2)07659; l(2)k11504; mig
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in imaginal disc-derived wing morphogenesis. Located in nucleus. Is expressed in embryonic brain; embryonic/larval midgut; larval ventral nerve cord; and organism. Orthologous to several human genes including ZNF197 (zinc finger protein 197); ZNF221 (zinc finger protein 221); and ZNF284 (zinc finger protein 284). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Location:
50E1-50E1; 2-69 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14173693..14182838)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10061198..10070343)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44368 Neighboring gene uncharacterized protein Neighboring gene Receptor expression enhancing protein B Neighboring gene mitochondrial ribosomal protein S16 Neighboring gene SAXO downstream of blistered Neighboring gene Vesicular GABA Transporter

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Su(Hw) interacts with Combgap to establish long-range chromatin contacts. Vorobyeva NE, et al. Epigenetics Chromatin, 2024 May 21. PMID 38773468, Free PMC Article
  2. Biometrical analysis of larval digging behavior in Drosophila melanogaster. Godoy-Herrera R. Behav Genet, 1994 Sep. PMID 7993319
  3. Combgap Promotes Ovarian Niche Development and Chromatin Association of EcR-Binding Regions in BR-C. Hitrik A, et al. PLoS Genet, 2016 Nov. PMID 27846223, Free PMC Article
  4. Developmental genetics of the mutant combgap in Drosophila melanogaster. I. Effect on the morphology and chaetotaxy of the prothoracic leg. Datta RK, et al. Genetics, 1971 Jun. PMID 5099237, Free PMC Article
  5. The Effects of Sexcombless on the Forelegs of Drosophila Melanogaster. Mukherjee AS. Genetics, 1965 Feb. PMID 17248233, Free PMC Article

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A search for co-factors identified the ubiquitously expressed Combgap (Cg) as a novel transcriptional partner that impedes cell cycle exit and interferes with Eya-So activity specifically in this context. Cg acts as a flexible transcriptional platform that contributes to numerous gene expression outcomes by a variety of mechanisms.
    Title: Pleiotropy in Drosophila organogenesis: Mechanistic insights from Combgap and the retinal determination gene network.
  2. Uncover a novel role for Eya and So in promoting cell cycle exit in the retinal second mitotic wave (SMW), a synchronized, terminal cell division that occurs several hours after passage of the furrow. We show that Combgap (Cg), a zinc-finger transcription factor, antagonizes Eya-So function in the SMW.
    Title: Antagonistic regulation of the second mitotic wave by Eyes absent-Sine oculis and Combgap coordinates proliferation and specification in the Drosophila retina.
  3. Polytene chromosome stains showed that Cg co-localizes with EcR, the major regulator of BR-C, at the BR-C locus and that EcR binding to chromatin was sensitive to changes in Cg levels
    Title: Combgap Promotes Ovarian Niche Development and Chromatin Association of EcR-Binding Regions in BR-C.
  4. Combgap binds to GTGT motifs, which are present within the regulatory regions of Polycomb group target genes. Genome-wide analyses suggest that Combgap may directly recruit Polyhomeotic, a Polycomb group protein.
    Title: Combgap contributes to recruitment of Polycomb group proteins in Drosophila.
  5. combgap relays wingless signal reception to the determination of cortical cell fate in the visual system
    Title: Combgap relays wingless signal reception to the determination of cortical cell fate in the Drosophila visual system.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in imaginal disc-derived wing morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
combgap
Names
CG8367-PA
CG8367-PB
CG8367-PC
CG8367-PD
CG8367-PF
CG8367-PI
CG8367-PJ
CG8367-PK
CG8367-PL
CG8367-PM
CG8367-PN
cg-PA
cg-PB
cg-PC
cg-PD
cg-PF
cg-PI
cg-PJ
cg-PK
cg-PL
cg-PM
cg-PN
comb gap
migraine
NP_001097306.2
  • unusual splice
NP_001286409.1
  • unusual splice
NP_001303348.1
  • unusual splice

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    14173693..14182838
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001103836.4 → NP_001097306.2  combgap, isoform L

    See identical proteins and their annotated locations for NP_001097306.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYD1, C9QPD9
    Conserved Domains (5) summary
    cd11674
    Location:491 → 603
    lambda-1; inner capsid protein lambda-1 or VP3
    COG5048
    Location:287 → 371
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:294 → 314
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:306 → 331
    zf-H2C2_2; Zinc-finger double domain
    cl00195
    Location:425 → 465
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

  2. NM_001103834.4 → NP_001097304.2  combgap, isoform J

    See identical proteins and their annotated locations for NP_001097304.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYD2, C9QPD9
    Conserved Domains (5) summary
    cd11674
    Location:479 → 591
    lambda-1; inner capsid protein lambda-1 or VP3
    COG5048
    Location:275 → 359
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:282 → 302
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:294 → 319
    zf-H2C2_2; Zinc-finger double domain
    cl00195
    Location:413 → 453
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

  3. NM_001103835.2 → NP_001097305.1  combgap, isoform F

    See identical proteins and their annotated locations for NP_001097305.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYD3, C9QPD9
    Conserved Domains (2) summary
    sd00017
    Location:274 → 294
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:286 → 311
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001316419.1 → NP_001303348.1  combgap, isoform N

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A126GUP1, Q9NI49
    Conserved Domains (4) summary
    cd11674
    Location:439 → 499
    lambda-1; inner capsid protein lambda-1 or VP3
    sd00017
    Location:188 → 208
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:285 → 310
    zf-H2C2_2; Zinc-finger double domain
    cl00195
    Location:320 → 360
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

  5. NM_001299480.1 → NP_001286409.1  combgap, isoform M

    See identical proteins and their annotated locations for NP_001286409.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LFC7, C9QPD9
    Conserved Domains (5) summary
    cd11674
    Location:539 → 599
    lambda-1; inner capsid protein lambda-1 or VP3
    COG5048
    Location:282 → 366
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:289 → 309
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:301 → 326
    zf-H2C2_2; Zinc-finger double domain
    cl00195
    Location:420 → 460
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

  6. NM_001144194.2 → NP_001137666.1  combgap, isoform I

    See identical proteins and their annotated locations for NP_001137666.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7YZE6, C9QPD9
    Conserved Domains (2) summary
    sd00017
    Location:282 → 302
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:294 → 319
    zf-H2C2_2; Zinc-finger double domain

  7. NM_166034.2 → NP_725362.1  combgap, isoform B

    See identical proteins and their annotated locations for NP_725362.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z9M3, C9QPD9
    Related
    FBpp0086656
    Conserved Domains (5) summary
    cd11674
    Location:479 → 591
    lambda-1; inner capsid protein lambda-1 or VP3
    COG5048
    Location:275 → 359
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:282 → 302
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:294 → 319
    zf-H2C2_2; Zinc-finger double domain
    cl00195
    Location:413 → 453
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

  8. NM_079014.3 → NP_523738.2  combgap, isoform D

    See identical proteins and their annotated locations for NP_523738.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E982, Q7KHK4, Q9NI49
    Related
    FBpp0086655
    Conserved Domains (2) summary
    sd00017
    Location:181 → 201
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:193 → 218
    zf-H2C2_2; Zinc-finger double domain

  9. NM_001299479.1 → NP_001286408.1  combgap, isoform K

    See identical proteins and their annotated locations for NP_001286408.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LF29, Q9NI49
    Conserved Domains (4) summary
    cd11674
    Location:424 → 484
    lambda-1; inner capsid protein lambda-1 or VP3
    sd00017
    Location:173 → 193
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:270 → 295
    zf-H2C2_2; Zinc-finger double domain
    cl00195
    Location:305 → 345
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

  10. NM_166036.2 → NP_725364.1  combgap, isoform C

    See identical proteins and their annotated locations for NP_725364.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z9M4, Q9NI49
    Related
    FBpp0086657
    Conserved Domains (5) summary
    cd11674
    Location:336 → 448
    lambda-1; inner capsid protein lambda-1 or VP3
    COG5048
    Location:132 → 216
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:139 → 159
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:151 → 176
    zf-H2C2_2; Zinc-finger double domain
    cl00195
    Location:270 → 310
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

  11. NM_166035.2 → NP_725363.1  combgap, isoform A

    See identical proteins and their annotated locations for NP_725363.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E982, Q7KHK4, Q9NI49
    Related
    FBpp0086658
    Conserved Domains (2) summary
    sd00017
    Location:181 → 201
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:193 → 218
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LF29 A0A0B4LF29
A0A0B4LFC7 A0A0B4LFC7
A0A126GUP1 A0A126GUP1
A1Z9M3 A1Z9M3
A1Z9M4 A1Z9M4
A8DYD1 A8DYD1
A8DYD2 A8DYD2
A8DYD3 A8DYD3
B7YZE6 B7YZE6
Q7KHK4 Q7KHK4
Q8IGK0 Q8IGK0
Q8T0L4 Q8T0L4
Q95RL3 Q95RL3
Q9GT73 Q9GT73
Q9NI49 Q9NI49

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