U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Erbin erbb2 interacting protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 365661, updated on 13-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Erbinprovided by RGD
Official Full Name
erbb2 interacting proteinprovided by RGD
Primary source
RGD:1562952
See related
Ensembl:ENSRNOG00000047137 AllianceGenome:RGD:1562952
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Erbb2i; Erbb2ip; RGD1562952
Summary
Predicted to enable signaling receptor binding activity. Predicted to be involved in several processes, including cellular response to tumor necrosis factor; negative regulation of nucleotide-binding activity oligomerization domain containing 2 signaling pathway; and regulation of gene expression. Predicted to act upstream of or within protein targeting. Is active in glutamatergic synapse; neuromuscular junction; and postsynaptic specialization. Orthologous to human ERBIN (erbb2 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 602.5), Lung (RPKM 563.4) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Erbin in Genome Data Viewer
Location:
2q13
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (36660399..36762584, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (34926962..35028440, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (33880860..33952806, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100556 Neighboring gene splicing regulatory glutamic acid and lysine rich protein 1 Neighboring gene AKT interacting protein, pseudogene 2 Neighboring gene uncharacterized LOC120100694

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Erbin interacts with TARP γ-2 for surface expression of AMPA receptors in cortical interneurons. Tao Y, et al. Nat Neurosci, 2013 Mar. PMID 23354328
  2. Erbin is a protein concentrated at postsynaptic membranes that interacts with PSD-95. Huang YZ, et al. J Biol Chem, 2001 Jun 1. PMID 11279080
  3. ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor. Borg JP, et al. Nat Cell Biol, 2000 Jul. PMID 10878805
  4. β2-AR-induced Her2 transactivation mediated by Erbin confers protection from apoptosis in cardiomyocytes. Shi M, et al. Int J Cardiol, 2013 Aug 20. PMID 22564389
  5. The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative splice variants of ERBIN and analysis of their tissue expression. Favre B, et al. J Biol Chem, 2001 Aug 31. PMID 11375975

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
  
involved_in embryo development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment or maintenance of epithelial cell apical/basal polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of monocyte chemotactic protein-1 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in neurotransmitter receptor transport postsynaptic membrane to endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein targeting ISO
Inferred from Sequence Orthology
more info
  
involved_in receptor clustering IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels ISO
Inferred from Sequence Orthology
more info
  
involved_in response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
involved_in response to muramyl dipeptide ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in hemidesmosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuromuscular junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic specialization IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic specialization IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
erbin

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427815.1 → NP_001414744.1  erbin

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I5ZWX2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    36660399..36762584 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063282246.1 → XP_063138316.1  erbin isoform X9

  2. XM_063282245.1 → XP_063138315.1  erbin isoform X7

  3. XM_063282244.1 → XP_063138314.1  erbin isoform X5

  4. XM_017591180.3 → XP_017446669.2  erbin isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZN42
    Conserved Domains (3) summary
    COG4886
    Location:70 → 402
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00992
    Location:1351 → 1437
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:24 → 47
    LRR_RI; leucine-rich repeat [structural motif]

  5. XM_039103492.2 → XP_038959420.1  erbin isoform X8

    UniProtKB/TrEMBL
    A0A8I5ZN42, A0A8I6A8N1
    Related
    ENSRNOP00000088858.1
    Conserved Domains (3) summary
    COG4886
    Location:70 → 402
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00992
    Location:1205 → 1290
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:24 → 47
    LRR_RI; leucine-rich repeat [structural motif]

  6. XM_017591184.3 → XP_017446673.2  erbin isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZN42, A0A8I6ACI5
    Related
    ENSRNOP00000091667.1
    Conserved Domains (3) summary
    COG4886
    Location:70 → 402
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00992
    Location:1273 → 1359
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:24 → 47
    LRR_RI; leucine-rich repeat [structural motif]

  7. XM_017591181.3 → XP_017446670.2  erbin isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZN42
    Conserved Domains (3) summary
    COG4886
    Location:70 → 402
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00992
    Location:1321 → 1407
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:24 → 47
    LRR_RI; leucine-rich repeat [structural motif]

  8. XM_039103490.2 → XP_038959418.1  erbin isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZN42, A0A8I6AE43
    Related
    ENSRNOP00000090634.1
    Conserved Domains (3) summary
    COG4886
    Location:70 → 402
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00992
    Location:1360 → 1446
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:24 → 47
    LRR_RI; leucine-rich repeat [structural motif]

  9. XM_063282243.1 → XP_063138313.1  erbin isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZWX2

  10. XM_017591179.3 → XP_017446668.2  erbin isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZN42, A0A8I6AE43
    Conserved Domains (3) summary
    COG4886
    Location:70 → 402
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00992
    Location:1360 → 1446
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:24 → 47
    LRR_RI; leucine-rich repeat [structural motif]

  11. XM_039103491.2 → XP_038959419.1  erbin isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZN42, A0A8I6AE43
    Related
    ENSRNOP00000066263.3
    Conserved Domains (3) summary
    COG4886
    Location:70 → 402
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00992
    Location:1360 → 1446
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:24 → 47
    LRR_RI; leucine-rich repeat [structural motif]

  12. XM_063282247.1 → XP_063138317.1  erbin isoform X10

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous