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PA polymerase [ Influenza A virus (A/goose/Guangdong/1/1996(H5N1)) ]

Gene ID: 3654617, updated on 10-May-2025
Gene symbol
PA
Gene description
polymerase
Locus tag
FLUAVH5N1_s3gp1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Influenza A virus (A/goose/Guangdong/1/1996(H5N1)) (strain: A/goose/Guangdong/1/1996, serotype: H5N1, nat-host: goose)
Lineage
Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina; Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus; Alphainfluenzavirus influenzae
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Try the new Transcripts and proteins table
Location:
segment: 3
Sequence:
NC_007359.1 (25..2175)

NC_007359.1Genomic Context describing neighboring genes Neighboring gene PA-X protein

Genomic Sequence:
NC_007359.1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. PA Mutations Inherited during Viral Evolution Act Cooperatively To Increase Replication of Contemporary H5N1 Influenza Virus with an Expanded Host Range. Arai Y, et al. J Virol, 2020 Dec 9. PMID 33028722, Free PMC Article
  2. Mutations in the PA Protein of Avian H5N1 Influenza Viruses Affect Polymerase Activity and Mouse Virulence. Zhong G, et al. J Virol, 2018 Feb 15. PMID 29212927, Free PMC Article
  3. The virulence factor PA protein of highly pathogenic H5N1 avian influenza virus inhibits NF-κB transcription in vitro. Cui Z, et al. Arch Virol, 2017 Nov. PMID 28744591
  4. Mammalian adaptive mutations of the PA protein of highly pathogenic avian H5N1 influenza virus. Yamaji R, et al. J Virol, 2015 Apr. PMID 25631084, Free PMC Article
  5. The PA protein directly contributes to the virulence of H5N1 avian influenza viruses in domestic ducks. Song J, et al. J Virol, 2011 Mar. PMID 21177821, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structures of H5N1 influenza polymerase with ANP32B reveal mechanisms of genome replication and host adaptation.
    Title: Structures of H5N1 influenza polymerase with ANP32B reveal mechanisms of genome replication and host adaptation.
  2. An in silico prediction of interaction models of influenza A virus PA and human C14orf166 protein from yeast-two-hybrid screening data.
    Title: An in silico prediction of interaction models of influenza A virus PA and human C14orf166 protein from yeast-two-hybrid screening data.
  3. PA Mutations Inherited during Viral Evolution Act Cooperatively To Increase Replication of Contemporary H5N1 Influenza Virus with an Expanded Host Range.
    Title: PA Mutations Inherited during Viral Evolution Act Cooperatively To Increase Replication of Contemporary H5N1 Influenza Virus with an Expanded Host Range.
  4. two amino acid changes in the viral polymerase PA protein affect the activity of the viral polymerase complex and virulence in mice
    Title: Mutations in the PA Protein of Avian H5N1 Influenza Viruses Affect Polymerase Activity and Mouse Virulence.
  5. This study showed that the PA protein of the highly pathogenic avian influenza virus strain CK10 had the strongest inhibitory effect on NF-kappaB activation when compared with other genes; PA also inhibited NF-kappaB-regulated inflammatory factors.
    Title: The virulence factor PA protein of highly pathogenic H5N1 avian influenza virus inhibits NF-κB transcription in vitro.
  6. FAK kinase activity is important in promoting influenza A virus subtypes replication by regulating its polymerase activity.
    Title: Focal adhesion kinase (FAK) regulates polymerase activity of multiple influenza A virus subtypes.
  7. The PA of an H5N1 influenza virus isolated from a human in Vietnam increased the ability of an avian H5N1 virus to grow in human lung epithelial A549 cells.
    Title: Mammalian adaptive mutations of the PA protein of highly pathogenic avian H5N1 influenza virus.
  8. A novel combination of substitutions in HA (H156N and S263R) and PA (I38M) led to the enhanced virulence of the H6N6 influenza A virus in mice.
    Title: A combination of HA and PA mutations enhances virulence in a mouse-adapted H6N6 influenza A virus.
  9. Although the PA from H5N1 is incidentally compatible with a seasonal H3N2 backbone, the H5N1 PA affected the virulence of seasonal H3N2, particularly in inflammasome-related innate immunity deficient mice.
    Title: Caspase-1 deficient mice are more susceptible to influenza A virus infection with PA variation.
  10. Polymerase PA subunit is a virulence factor for H5N1 AIVs in ducks.
    Title: The PA protein directly contributes to the virulence of H5N1 avian influenza viruses in domestic ducks.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Homology

Preferred Names
polymerase

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007359.1 Reference assembly

    Range
    25..2175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_308666.1 polymerase [Influenza A virus (A/goose/Guangdong/1/1996(H5N1))]

    See identical proteins and their annotated locations for YP_308666.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9Q0U9
    UniProtKB/TrEMBL
    Q91R78
    Conserved Domains (1) summary
    pfam00603
    Location:21 → 715
    Flu_PA; Influenza RNA-dependent RNA polymerase subunit PA
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Q0U9.1

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