Trpm5 transient receptor potential cation channel, subfamily M, member 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trpm5provided by RGD
Official Full Name: transient receptor potential cation channel, subfamily M, member 5provided by RGD
Primary source: RGD:1310620
See related: Ensembl:ENSRNOG00000020484 AllianceGenome:RGD:1310620
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable calcium-activated cation channel activity; potassium channel activity; and sodium channel activity. Predicted to be involved in metal ion transport; monoatomic cation transmembrane transport; and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to act upstream of or within monoatomic ion transmembrane transport. Located in dendrite and neuronal cell body. Orthologous to human TRPM5 (transient receptor potential cation channel subfamily M member 5). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Lung (RPKM 15.8), Uterus (RPKM 4.5) and 8 other tissues See more
Orthologs: all
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Genomic context

Location:: 1q42

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (207684811..207707380, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (198254956..198277824, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (216256653..216281504, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Ca(2+)-binding sites of TRPM4 and TRPM5 were shown to be formed by the same amino acid residues by functional analyses, but the impact of PI(4,5)P2 on the regulation of TRPM5 seemed to be smaller than that on the regulation of TRPM4.
Title: TRPM4 and TRPM5 Channels Share Crucial Amino Acid Residues for Ca(2+) Sensitivity but Not Significance of PI(4,5)P(2).
conclude that nAChR subunits are expressed in Trpm5-positive TRCs and their expression levels are differentially altered by chronic oral exposure to nicotine and ethanol
Title: Nicotinic acetylcholine receptors (nAChRs) are expressed in Trpm5 positive taste receptor cells (TRCs).
Sweet taste molecules of T1R2, T1R3, alpha-gustducin and TRPM5 in ileum were dramatically higher than those in duodenum (P<0.01 for each).
Title: Expression of sweet taste receptor and gut hormone secretion in modelled type 2 diabetes.
In rat pancreatic islets, TRPM5 is involved in mediating insulin secretion by glucose and l-arginine and in potentiating the glucose-induced insulin secretion by glucagon-like peptide 1.
Title: Role of transient receptor potential melastatin-like subtype 5 channel in insulin secretion from rat β-cells.
The results suggest that pharmacological or genetic alteration of TRPM5 activity modulates the benzamil-insensitive NaCl chorda tympani response and its modulation by TRPV1 agonists.
Title: TRPM5-dependent amiloride- and benzamil-insensitive NaCl chorda tympani taste nerve response.
These channels may play an important role in determining the distinct firing properties of vasopressin neurones in the supraoptic nucleus.
Title: Transient receptor potential channel m4 and m5 in magnocellular cells in rat supraoptic and paraventricular nuclei.

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General gene information

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Markers

UniSTS:496001 (e-PCR)
- UniSTS:496001

Trpm5 (e-PCR), detects polymorphism
- UniSTS:496001

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium-activated cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-activated cation channel activity	IEA Inferred from Electronic Annotation more info
enables calcium-activated cation channel activity	ISO Inferred from Sequence Orthology more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	ISO Inferred from Sequence Orthology more info
enables monoatomic ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables potassium channel activity	IEA Inferred from Electronic Annotation more info
enables potassium channel activity	ISO Inferred from Sequence Orthology more info
enables sodium channel activity	IEA Inferred from Electronic Annotation more info
enables sodium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in metal ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in metal ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic cation transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transient receptor potential cation channel subfamily M member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191896.2 → NP_001178825.2 transient receptor potential cation channel subfamily M member 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A455XI77, A0A8I6AG64

Related

ENSRNOP00000091726.1, ENSRNOT00000103945.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

207684811..207707380 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085432.2 → XP_038941360.1 transient receptor potential cation channel subfamily M member 5 isoform X1

UniProtKB/TrEMBL

A0A455XI77, A0A8I6AG64

Conserved Domains (2) summary

TIGR00870
Location:717 → 1106

trp; transient-receptor-potential calcium channel protein

cl39032
Location:47 → 273

LSDAT_euk; SLOG in TRPM
XM_039085435.2 → XP_038941363.1 transient receptor potential cation channel subfamily M member 5 isoform X2

UniProtKB/TrEMBL

A6HYA7

Conserved Domains (2) summary

pfam00520
Location:746 → 878

Ion_trans; Ion transport protein

cl39032
Location:47 → 273

LSDAT_euk; SLOG in TRPM