Alpk3 alpha-kinase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Alpk3provided by RGD
Official Full Name: alpha-kinase 3provided by RGD
Primary source: RGD:1309860
See related: Ensembl:ENSRNOG00000011659 AllianceGenome:RGD:1309860
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1309860
Summary: Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in cardiac muscle cell development. Predicted to act upstream of or within heart development. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy 27. Orthologous to human ALPK3 (alpha kinase 3). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Muscle (RPKM 817.0), Heart (RPKM 405.5) and 1 other tissue See more
Orthologs: all
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Genomic context

Location:: 1q31

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (144423690..144471534)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (135014455..135062294)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (142882997..142931940)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fj64a08.x1 (e-PCR)
- UniSTS:199729

fd21c02.x1 (e-PCR)
- UniSTS:195252

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cardiac muscle cell development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cardiac muscle cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha-protein kinase 3

NP_001178824.1

EC 2.7.11.1

XP_008757768.1

EC 2.7.11.1

XP_038940952.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191895.2 → NP_001178824.1 alpha-protein kinase 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0ABK0KWX8, D3ZH28

Related

ENSRNOP00000015899.4, ENSRNOT00000015898.7

Conserved Domains (4) summary

smart00408
Location:90 → 159

IGc2; Immunoglobulin C-2 Type

smart00410
Location:1271 → 1343

IG_like; Immunoglobulin like

smart00811
Location:1376 → 1596

Alpha_kinase; Alpha-kinase family

pfam07679
Location:77 → 169

I-set; Immunoglobulin I-set domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

144423690..144471534

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085024.2 → XP_038940952.1 alpha-protein kinase 3 isoform X2

UniProtKB/TrEMBL

A0ABK0KWX8

Conserved Domains (3) summary

PHA03307
Location:882 → 1254

PHA03307; transcriptional regulator ICP4; Provisional

cd00096
Location:77 → 79

Ig; Ig strand A [structural motif]

cl11960
Location:77 → 169

Ig; Immunoglobulin domain
XM_008759546.4 → XP_008757768.1 alpha-protein kinase 3 isoform X1

UniProtKB/TrEMBL

A0A8I6A4R0, A0ABK0KWX8

Related

ENSRNOP00000088261.1, ENSRNOT00000117513.2

Conserved Domains (4) summary

smart00408
Location:77 → 146

IGc2; Immunoglobulin C-2 Type

smart00410
Location:1258 → 1330

IG_like; Immunoglobulin like

smart00811
Location:1363 → 1583

Alpha_kinase; Alpha-kinase family

pfam07679
Location:64 → 156

I-set; Immunoglobulin I-set domain