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IPP intracisternal A particle-promoted polypeptide [ Homo sapiens (human) ]

Gene ID: 3652, updated on 7-Jun-2020

Summary

Official Symbol
IPPprovided by HGNC
Official Full Name
intracisternal A particle-promoted polypeptideprovided by HGNC
Primary source
HGNC:HGNC:6108
See related
Ensembl:ENSG00000197429 MIM:147485
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KLHL27
Summary
The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 50 amino acid repeat which interacts with actin. Transcript variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 2.7), testis (RPKM 2.4) and 25 other tissues See more
Orthologs

Genomic context

See IPP in Genome Data Viewer
Location:
1p34.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (45694324..45750813, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (46159996..46216485, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene GC-rich promoter binding protein 1 like 1 Neighboring gene ribosomal protein S15a pseudogene 10 Neighboring gene ribosomal protein L7a pseudogene 16 Neighboring gene transmembrane protein 69 Neighboring gene uncharacterized LOC105378693 Neighboring gene ribosomal protein L6 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
actin cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
actin-binding protein IPP
Names
kelch-like family member 27
kelch-like protein 27

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145349.1NP_001138821.1  actin-binding protein IPP isoform 2

    See identical proteins and their annotated locations for NP_001138821.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site and alternate exon in the 3' coding region compared to variant 1, that results in a frameshift. This variant encodes isoform 2, which has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK023880, BC032544, DA905423
    Consensus CDS
    CCDS44132.1
    UniProtKB/Swiss-Prot
    Q9Y573
    Related
    ENSP00000353024.4, ENST00000359942.8
    Conserved Domains (2) summary
    PHA03098
    Location:30540
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:333376
    Kelch; KELCH repeat [structural motif]
  2. NM_005897.3NP_005888.1  actin-binding protein IPP isoform 1

    See identical proteins and their annotated locations for NP_005888.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK023880, AL604028, DA905423
    Consensus CDS
    CCDS30702.1
    UniProtKB/Swiss-Prot
    Q9Y573
    Related
    ENSP00000379739.3, ENST00000396478.4
    Conserved Domains (2) summary
    PHA03098
    Location:30575
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:333376
    Kelch; KELCH repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    45694324..45750813 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006710623.4XP_006710686.1  actin-binding protein IPP isoform X4

    Conserved Domains (5) summary
    smart00612
    Location:392437
    Kelch; Kelch domain
    smart00225
    Location:38134
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00038
    Location:333377
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:28131
    BTB; BTB/POZ domain
    pfam07707
    Location:139241
    BACK; BTB And C-terminal Kelch
  2. XM_005270839.5XP_005270896.1  actin-binding protein IPP isoform X3

    See identical proteins and their annotated locations for XP_005270896.1

    Conserved Domains (5) summary
    smart00612
    Location:392437
    Kelch; Kelch domain
    smart00225
    Location:38134
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00038
    Location:333377
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:28131
    BTB; BTB/POZ domain
    pfam07707
    Location:139241
    BACK; BTB And C-terminal Kelch
  3. XM_024446763.1XP_024302531.1  actin-binding protein IPP isoform X1

    Conserved Domains (2) summary
    PHA03098
    Location:30575
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:333376
    Kelch; KELCH repeat [structural motif]
  4. XM_017001210.2XP_016856699.1  actin-binding protein IPP isoform X2

  5. XM_011541394.3XP_011539696.1  actin-binding protein IPP isoform X3

    See identical proteins and their annotated locations for XP_011539696.1

    Conserved Domains (5) summary
    smart00612
    Location:392437
    Kelch; Kelch domain
    smart00225
    Location:38134
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00038
    Location:333377
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:28131
    BTB; BTB/POZ domain
    pfam07707
    Location:139241
    BACK; BTB And C-terminal Kelch

RNA

  1. XR_001737155.2 RNA Sequence

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