Cfap53 cilia and flagella associated protein 53 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cfap53provided by RGD
Official Full Name: cilia and flagella associated protein 53provided by RGD
Primary source: RGD:1306734
See related: Ensembl:ENSRNOG00000014585 AllianceGenome:RGD:1306734
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ccdc11; RGD1306734
Summary: Predicted to be involved in determination of left/right symmetry; manchette assembly; and sperm flagellum assembly. Predicted to act upstream of or within several processes, including epithelial cilium movement involved in extracellular fluid movement; flagellated sperm motility; and protein localization to motile cilium. Predicted to be located in several cellular components, including ciliary transition zone; microtubule cytoskeleton; and motile cilium. Predicted to be active in axonemal A tubule inner sheath and sperm flagellum. Human ortholog(s) of this gene implicated in visceral heterotaxy 6. Orthologous to human CFAP53 (cilia and flagella associated protein 53). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Biased expression in Testes (RPKM 108.6), Lung (RPKM 16.7) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (70159900..70227543)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (67884651..67955873)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (70263290..70330420)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables double-stranded methylated DNA binding	IEA Inferred from Electronic Annotation more info
enables methyl-CpG binding	IEA Inferred from Electronic Annotation more info
enables unmethylated CpG binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell projection organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cerebrospinal fluid circulation	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in determination of left/right symmetry	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cilium movement involved in determination of left/right asymmetry	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in manchette assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to motile cilium	ISO Inferred from Sequence Orthology more info
involved_in sperm flagellum assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in 9+0 motile cilium	ISO Inferred from Sequence Orthology more info
located_in 9+2 motile cilium	ISO Inferred from Sequence Orthology more info
is_active_in axonemal A tubule inner sheath	ISO Inferred from Sequence Orthology more info
located_in axonemal microtubule	ISO Inferred from Sequence Orthology more info
located_in axoneme	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in ciliary transition zone	ISO Inferred from Sequence Orthology more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cilium	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in glial cell projection	ISO Inferred from Sequence Orthology more info
located_in manchette	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in polymeric cytoskeletal fiber	IEA Inferred from Electronic Annotation more info
is_active_in sperm flagellum	ISO Inferred from Sequence Orthology more info
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cilia and flagella associated protein 53; cilia- and flagella-associated protein 53

Names: coiled-coil domain containing 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001432462.1 → NP_001419391.1 cilia and flagella associated protein 53 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

UniProtKB/TrEMBL

F1M6S6
NM_001432463.1 → NP_001419392.1 cilia and flagella associated protein 53 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

UniProtKB/TrEMBL

A0A8I6A3Z8, A6KRF4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

70159900..70227543

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_344700.11 → XP_344701.3 cilia- and flagella-associated protein 53 isoform X1

Related

ENSRNOP00000087326.2, ENSRNOT00000097630.2

Conserved Domains (1) summary

pfam13868
Location:189 → 518

TPH; Trichohyalin-plectin-homology domain
XM_017601132.3 → XP_017456621.1 cilia- and flagella-associated protein 53 isoform X2