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Su(z)2 Suppressor of zeste 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36432, updated on 6-Jul-2026
Official Symbol
Su(z)2provided by FlyBase
Official Full Name
Suppressor of zeste 2provided by FlyBase
Primary source
FLYBASE:FBgn0265623
Locus tag
Dmel_CG3905
See related
AllianceGenome:FB:FBgn0265623
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Arp; CG3905; Dmel\CG3905; l(2)k06344; su(z)2; Su(Z)2; SU(Z)2; Su(z)2D; su(z)3; Su(z)3; Su(z)[[2]]; Suz2; SUZ2
Summary
Enables DNA binding activity. Involved in heterochromatin formation. Located in nucleus. Part of PRC1 complex. Orthologous to human PCGF1 (polycomb group ring finger 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See Su(z)2 in Genome Data Viewer
Location:
49E7-49E7; 2-67 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12996501..13007911)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8884006..8895416)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44339 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. An Unexpected Regulatory Cascade Governs a Core Function of the Drosophila PRC1 Chromatin Protein Su(z)2. Nguyen SC, et al. Genetics, 2017 Feb. PMID 27881472, Free PMC Article
  2. The sequence of the Drosophila regulatory gene Suppressor two of zeste. Brunk BP, et al. Nucleic Acids Res, 1991 Jun 11. PMID 2057369, Free PMC Article
  3. The vestigial locus of Drosophila melanogaster is involved in resistance to inhibitors of dTMP synthesis. Silber J, et al. Mol Gen Genet, 1993 Oct. PMID 8232210
  4. Ubiquitylome study identifies increased histone 2A ubiquitylation as an evolutionarily conserved aging biomarker. Yang L, et al. Nat Commun, 2019 May 21. PMID 31113955, Free PMC Article
  5. Sequence similarity between the mammalian bmi-1 proto-oncogene and the Drosophila regulatory genes Psc and Su(z)2. van Lohuizen M, et al. Nature, 1991 Sep 26. PMID 1922340

See all (216) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutations in Su(z)2 increase fly survival. This protein influences on Life Span via pathways independent of its Polycomb Repressive Complex 1 functions, with distinct effects on response to Oxidative Stress.
    Title: Epigenetic factors Polycomb (Pc) and Suppressor of zeste (Su(z)2) negatively regulate longevity in Drosophila melanogaster.
  2. Core activity of Su(z)2 seems to reside in the N-terminal homology region. C-terminal region is dispensable for viability. Data also suggest a regulatory cascade between C-terminus and homology region.
    Title: An Unexpected Regulatory Cascade Governs a Core Function of the Drosophila PRC1 Chromatin Protein Su(z)2.
  3. Psc and Su(z)2 maintain somatic stem cell identity and activity in Drosophila.
    Title: Polycomb group genes Psc and Su(z)2 maintain somatic stem cell identity and activity in Drosophila.
  4. The Psc-Su(z)2 locus is flanked by insulator elements that may protect neighboring genes from inappropriate silencing.
    Title: Regulation of Polycomb group genes Psc and Su(z)2 in Drosophila melanogaster.
  5. Posterior sex combs (Psc), which encodes a core Polycomb-repressive complex 1 (PRC1) component, functions redundantly with a similar gene, Suppressor of zeste two [Su(z)2], to restrict follicle stem cell (FSC) self-renewal in the Drosophila ovary
    Title: Polycomb group genes Psc and Su(z)2 restrict follicle stem cell self-renewal and extrusion by controlling canonical and noncanonical Wnt signaling.
  6. results establish Suppressor 2 of zeste as a functional homolog of Posterior Sex Combs and suggest that the two proteins operate via similar molecular mechanisms
    Title: Polycomb group protein Suppressor 2 of zeste is a functional homolog of Posterior Sex Combs.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables promoter-specific chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in heterochromatin formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heterochromatin formation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of PRC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of PRC1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of PRC1 complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in chromatin NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
suppressor of zeste 2
Names
CG3905-PA
CG3905-PB
CG3905-PC
Su(z)2-PA
Su(z)2-PB
Su(z)2-PC
aristapedioid
aristopedoid
suppressor 2 of zeste
suppressor of zeste (2)
suppressor of zeste (3)
suppressor of zeste 3
suppressor of zeste two
suppressor two of zeste
supressor of zeste 2

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    12996501..13007911
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169663.3 → NP_001163134.1  suppressor of zeste 2, isoform B

    See identical proteins and their annotated locations for NP_001163134.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P25172, Q9V6J0
    UniProtKB/TrEMBL
    E1JH51, H6QXK0, H6QXK1
    Conserved Domains (2) summary
    pfam00097
    Location:35 → 73
    zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
    pfam16207
    Location:143 → 228
    RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like

  2. NM_001274004.1 → NP_001260933.1  suppressor of zeste 2, isoform C

    See identical proteins and their annotated locations for NP_001260933.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEM5, H6QXK0, H6QXK1
    Conserved Domains (2) summary
    pfam00097
    Location:35 → 73
    zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
    pfam16207
    Location:143 → 228
    RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like

  3. NM_079002.3 → NP_523726.2  suppressor of zeste 2, isoform A

    See identical proteins and their annotated locations for NP_523726.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P25172, Q9V6J0
    UniProtKB/TrEMBL
    E1JH51, H6QXK0, H6QXK1
    Related
    FBpp0086906
    Conserved Domains (2) summary
    pfam00097
    Location:35 → 73
    zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
    pfam16207
    Location:143 → 228
    RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KEM5 A0A0B4KEM5
E1JH51 E1JH51
P25172.2 P25172

Gene LinkOut

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