Plek pleckstrin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Plekprovided by RGD
Official Full Name: pleckstrinprovided by RGD
Primary source: RGD:1308269
See related: Ensembl:ENSRNOG00000005214 AllianceGenome:RGD:1308269
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable phosphatidylinositol-3,4-bisphosphate binding activity; protein homodimerization activity; and protein kinase C binding activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; exocytosis; and positive regulation of cellular component organization. Predicted to be located in cytoplasm and ruffle membrane. Predicted to be active in plasma membrane. Orthologous to human PLEK (pleckstrin). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Biased expression in Spleen (RPKM 536.7), Lung (RPKM 107.4) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (95598650..95631326, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (91397015..91429693, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (100151518..100184192, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatase activator activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activator activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4-bisphosphate binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase C binding	IEA Inferred from Electronic Annotation more info
enables protein kinase C binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in cell projection organization	ISO Inferred from Sequence Orthology more info
involved_in cortical actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in cortical actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in hematopoietic progenitor cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in inositol phosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in inositol phosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of inositol phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of thrombin-activated receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of thrombin-activated receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-inhibiting G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in platelet aggregation	IEA Inferred from Electronic Annotation more info
involved_in platelet aggregation	ISO Inferred from Sequence Orthology more info
involved_in platelet degranulation	IEA Inferred from Electronic Annotation more info
involved_in platelet degranulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of actin filament bundle assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of actin filament depolymerization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of actin filament depolymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cellular component biogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of integrin activation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of integrin activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of platelet activation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of platelet activation	ISO Inferred from Sequence Orthology more info
involved_in protein secretion by platelet	IEA Inferred from Electronic Annotation more info
involved_in protein secretion by platelet	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell diameter	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell diameter	ISO Inferred from Sequence Orthology more info
involved_in ruffle organization	IEA Inferred from Electronic Annotation more info
involved_in ruffle organization	ISO Inferred from Sequence Orthology more info
involved_in thrombin-activated receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in thrombin-activated receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in vesicle docking involved in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in vesicle docking involved in exocytosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pleckstrin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025750.1 → NP_001020921.1 pleckstrin

See identical proteins and their annotated locations for NP_001020921.1

Status: PROVISIONAL

Source sequence(s)

BC098846

UniProtKB/Swiss-Prot

Q4KM33

UniProtKB/TrEMBL

A0A8I6ANN0, A6JPY3

Related

ENSRNOP00000007044.3, ENSRNOT00000007044.7

Conserved Domains (4) summary

cd04445
Location:125 → 223

DEP_PLEK1; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in pleckstrin 1-like proteins. Pleckstrin 1 plays a role in cell spreading and reorganization of actin cytoskeleton in platelets and leukocytes. Its activity is highly regulated by phosphorylation, ...

cd13301
Location:3 → 110

PH1_Pleckstrin_2; Pleckstrin 2 Pleckstrin homology (PH) domain, repeat 1

cd13302
Location:239 → 346

PH2_Pleckstrin_2; Pleckstrin 2 Pleckstrin homology (PH) domain, repeat 2

pfam00169
Location:6 → 101

PH; PH domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

95598650..95631326 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006251520.1 → XP_006251582.1 pleckstrin isoform X1

See identical proteins and their annotated locations for XP_006251582.1

UniProtKB/Swiss-Prot

Q4KM33

UniProtKB/TrEMBL

A0A8I6ANN0, A6JPY3

Related

ENSRNOP00000083092.2, ENSRNOT00000094345.2

Conserved Domains (4) summary

cd04445
Location:125 → 223

DEP_PLEK1; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in pleckstrin 1-like proteins. Pleckstrin 1 plays a role in cell spreading and reorganization of actin cytoskeleton in platelets and leukocytes. Its activity is highly regulated by phosphorylation, ...

cd13301
Location:3 → 110

PH1_Pleckstrin_2; Pleckstrin 2 Pleckstrin homology (PH) domain, repeat 1

cd13302
Location:239 → 346

PH2_Pleckstrin_2; Pleckstrin 2 Pleckstrin homology (PH) domain, repeat 2

pfam00169
Location:6 → 101

PH; PH domain