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INSM1 INSM transcriptional repressor 1 [ Homo sapiens (human) ]

Gene ID: 3642, updated on 29-Mar-2020

Summary

Official Symbol
INSM1provided by HGNC
Official Full Name
INSM transcriptional repressor 1provided by HGNC
Primary source
HGNC:HGNC:6090
See related
Ensembl:ENSG00000173404 MIM:600010
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IA1; IA-1
Summary
Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors. [provided by RefSeq, Jul 2008]
Orthologs

Genomic context

See INSM1 in Genome Data Viewer
Location:
20p11.23
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (20368104..20370949)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (20348765..20351593)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 61 Neighboring gene CFAP61 antisense RNA 1 Neighboring gene RNA, 7SL, cytoplasmic 690, pseudogene Neighboring gene Ral GTPase activating protein catalytic subunit alpha 2 Neighboring gene VISTA enhancer hs688 Neighboring gene eukaryotic translation initiation factor 4E family member 2 pseudogene 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of insulinoma-associated 1 (INSM1) in peptide-treated PBMCs PubMed
Tat tat HIV-1 Tat downregulates insulinoma-associated 1 in HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
cyclin binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
adrenal chromaffin cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
endocrine pancreas development TAS
Traceable Author Statement
more info
 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
noradrenergic neuron development ISS
Inferred from Sequence or Structural Similarity
more info
 
norepinephrine biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
pancreatic A cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neural precursor cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell cycle process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of protein complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
sympathetic ganglion development ISS
Inferred from Sequence or Structural Similarity
more info
 
transdifferentiation IDA
Inferred from Direct Assay
more info
PubMed 
type B pancreatic cell development IEA
Inferred from Electronic Annotation
more info
 
type B pancreatic cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
transcriptional repressor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcriptional repressor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
insulinoma-associated protein 1
Names
insulinoma-associated 1
zinc finger protein IA-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002196.3NP_002187.1  insulinoma-associated protein 1

    See identical proteins and their annotated locations for NP_002187.1

    Status: REVIEWED

    Source sequence(s)
    AL161658
    Consensus CDS
    CCDS13143.1
    UniProtKB/Swiss-Prot
    Q01101
    Related
    ENSP00000312631.1, ENST00000310227.3
    Conserved Domains (2) summary
    sd00017
    Location:269289
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:367389
    zf-C2H2; Zinc finger, C2H2 type

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    20368104..20370949
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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