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Cyp9h1 Cytochrome P450 9h1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36412, updated on 4-Jan-2025

Summary

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Official Symbol
Cyp9h1provided by FlyBase
Official Full Name
Cytochrome P450 9h1provided by FlyBase
Primary source
FLYBASE:FBgn0033775
Locus tag
Dmel_CG17577
See related
AllianceGenome:FB:FBgn0033775
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
9h1; CG17577; CYP9H1; Dmel\CG17577
Summary
Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head and embryonic/larval midgut. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; essential hypertension; and familial Mediterranean fever. Orthologous to several human genes including CYP3A7-CYP3A51P (CYP3A7-CYP3A51P readthrough); CYP3A4 (cytochrome P450 family 3 subfamily A member 4); and CYP3A43 (cytochrome P450 family 3 subfamily A member 43). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Cyp9h1 in Genome Data Viewer
Location:
49D4-49D4; 2-67 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12840813..12842558, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8728318..8730063, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44453 Neighboring gene Odorant receptor 49b Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RNA interference validation of detoxification genes involved in ivermectin tolerance in Drosophila melanogaster. Kim JH, et al. Insect Mol Biol, 2018 Oct. PMID 29888824
  2. Differential expression and induction of two Drosophila cytochrome P450 genes near the Rst(2)DDT locus. Brandt A, et al. Insect Mol Biol, 2002 Aug. PMID 12144699
  3. Structural Modeling of Drosophila melanogaster Gut Cytochrome P450s and Docking Comparison of Fruit Fly Gut and Human Cytochrome P450s. Nirusimhan V, et al. Curr Drug Metab, 2022. PMID 35546755
  4. Genes and pathways affected by CAG-repeat RNA-based toxicity in Drosophila. Shieh SY, et al. Hum Mol Genet, 2011 Dec 15. PMID 21933837, Free PMC Article
  5. The DHR96 nuclear receptor regulates xenobiotic responses in Drosophila. King-Jones K, et al. Cell Metab, 2006 Jul. PMID 16814731

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome P450 9h1
Names
CG17577-PA
Cyp9h1-PA
cytochrome P450
NP_610820.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    12840813..12842558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136976.2 → NP_610820.1  cytochrome P450 9h1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610820.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V6H1
    UniProtKB/TrEMBL
    F3YDG1
    Related
    FBpp0086933
    Conserved Domains (1) summary
    pfam00067
    Location:38 → 512
    p450; Cytochrome P450
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V6H1.1 Q9V6H1

Gene LinkOut

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