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RTT109 H3 histone acetyltransferase [ Candida albicans SC5314 ]

Gene ID: 3639678, updated on 25-Aug-2025
Gene symbol
RTT109
Gene description
H3 histone acetyltransferase
Locus tag
CAALFM_CR00410WA
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Candida albicans SC5314 (strain: SC5314, nat-host: Homo sapiens, culture-collection: ATCC:MYA-2876)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Pichiomycetes; Debaryomycetaceae; Candida/Lodderomyces clade; Candida
Orthologs
all
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See RTT109 in Genome Data Viewer
Location:
chromosome: R
Exon count:
1
Sequence:
Chromosome: R; NC_032096.1 (104225..105304)

Chromosome R - NC_032096.1Genomic Context describing neighboring genes Neighboring gene Mms22p Neighboring gene Swc4p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic Sequence:
NC_032096.1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A cell-free fluorometric high-throughput screen for inhibitors of Rtt109-catalyzed histone acetylation. Dahlin JL, et al. PLoS One, 2013. PMID 24260132, Free PMC Article
  2. Regulation of white and opaque cell-type formation in Candida albicans by Rtt109 and Hst3. Stevenson JS, et al. Mol Microbiol, 2011 Aug. PMID 21749487, Free PMC Article
  3. Histone acetyltransferase Rtt109 is required for Candida albicans pathogenesis. Lopes da Rosa J, et al. Proc Natl Acad Sci U S A, 2010 Jan 26. PMID 20080646, Free PMC Article
  4. Characterization of a novel separase-interacting protein and candidate new securin, Eip1p, in the fungal pathogen Candida albicans. Sparapani S, et al. Mol Biol Cell, 2019 Sep 1. PMID 31411946, Free PMC Article
  5. Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure. Muzzey D, et al. Genome Biol, 2013. PMID 24025428, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A cell-free fluorometric high-throughput screen for inhibitors of Rtt109-catalyzed histone acetylation.
    Title: A cell-free fluorometric high-throughput screen for inhibitors of Rtt109-catalyzed histone acetylation.
  2. Together, these findings suggest RTT109 and HST3 genes play an important role in the regulation of white-opaque switching in Candida albicans.
    Title: Regulation of white and opaque cell-type formation in Candida albicans by Rtt109 and Hst3.
  3. show that the increased sensitivity of rtt109(-/-) cells to macrophages depends on the host's ability to generate reactive oxygen species.
    Title: Histone acetyltransferase Rtt109 is required for Candida albicans pathogenesis.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables histone H3K56 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
H3 histone acetyltransferase
XP_718648.1
  • Histone acetyltransferase, mutants are sensitive to DNA damage, show decreased virulence in mice, decreased white-to-opaque switching and increased susceptibility to killing by macrophages

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_032096.1 Reference assembly

    Range
    104225..105304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_713555.1 → XP_718648.1  H3 histone acetyltransferase

    See identical proteins and their annotated locations for XP_718648.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    A0A1D8PRQ8, Q5AAJ8
    UniProtKB/TrEMBL
    A0A8H6C4H8, A0AB34PMQ4, C4YNE3
    Conserved Domains (1) summary
    cl02120
    Location:6 → 356
    HAT_KAT11; Histone acetylation protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5AAJ8.1

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials