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Elavl1 ELAV like RNA binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363854, updated on 5-Sep-2021

Summary

Official Symbol
Elavl1provided by RGD
Official Full Name
ELAV like RNA binding protein 1provided by RGD
Primary source
RGD:1308649
See related
Ensembl:ENSRNOG00000001069
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
HuR; Hua
Summary
RNA binding protein; involved in posttranscriptional regulation of VEGF expression [RGD, Feb 2006]
Expression
Biased expression in Thymus (RPKM 404.5), Spleen (RPKM 326.3) and 9 other tissues See more
Orthologs
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Genomic context

See Elavl1 in Genome Data Viewer
Location:
12p12
Exon count:
8
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (2640936..2684787, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (2461502..2502432)

Chromosome 12 - NC_051347.1Genomic Context describing neighboring genes Neighboring gene cortexin 1 Neighboring gene translocase of inner mitochondrial membrane 44 Neighboring gene uncharacterized LOC102552452 Neighboring gene C-C motif chemokine ligand 25

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables long noncoding RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA 3'-UTR AU-rich region binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA 3'-UTR AU-rich region binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables miRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables miRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in 3'-UTR-mediated mRNA stabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within mRNA stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA stabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of gene silencing by miRNA ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene silencing by miRNA ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in posttranscriptional gene silencing ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homooligomerization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic stress granule ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
located_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
ELAV-like protein 1
Names
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)
ELAV like 1
hu-antigen R
mRNA-stabilizing factor HuR

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108848.1NP_001102318.1  ELAV-like protein 1

    See identical proteins and their annotated locations for NP_001102318.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474084
    UniProtKB/Swiss-Prot
    B5DF91
    Related
    ENSRNOP00000001415.5, ENSRNOT00000001415.6
    Conserved Domains (1) summary
    TIGR01661
    Location:19326
    ELAV_HUD_SF; ELAV/HuD family splicing factor

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051347.1 Reference mRatBN7.2 Primary Assembly

    Range
    2640936..2684787 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089621.1XP_038945549.1  ELAV-like protein 1 isoform X1

    Conserved Domains (1) summary
    TIGR01661
    Location:19326
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  2. XM_039089620.1XP_038945548.1  ELAV-like protein 1 isoform X1

    Conserved Domains (1) summary
    TIGR01661
    Location:19326
    ELAV_HUD_SF; ELAV/HuD family splicing factor
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