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Elavl1 ELAV like RNA binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363854, updated on 4-Jun-2020

Summary

Official Symbol
Elavl1provided by RGD
Official Full Name
ELAV like RNA binding protein 1provided by RGD
Primary source
RGD:1308649
See related
Ensembl:ENSRNOG00000001069
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
HuR; Hua
Summary
RNA binding protein; involved in posttranscriptional regulation of VEGF expression [RGD, Feb 2006]
Expression
Biased expression in Thymus (RPKM 404.5), Spleen (RPKM 326.3) and 9 other tissues See more
Orthologs

Genomic context

See Elavl1 in Genome Data Viewer
Location:
12p12
Exon count:
6
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (2461502..2502432)
106 current Rn_Celera (GCF_000002265.2) 12 AC_000080.1 (4459379..4500318, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 12 NC_005111.3 (4614839..4655379)

Chromosome 12 - NC_005111.4Genomic Context describing neighboring genes Neighboring gene C-C motif chemokine ligand 25 Neighboring gene uncharacterized LOC102552452 Neighboring gene translocase of inner mitochondrial membrane 44 Neighboring gene cortexin 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
AU-rich element binding ISO
Inferred from Sequence Orthology
more info
 
AU-rich element binding ISS
Inferred from Sequence or Structural Similarity
more info
 
RNA binding ISO
Inferred from Sequence Orthology
more info
 
double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
mRNA 3'-UTR AU-rich region binding ISO
Inferred from Sequence Orthology
more info
 
mRNA 3'-UTR AU-rich region binding ISS
Inferred from Sequence or Structural Similarity
more info
 
mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
mRNA binding ISO
Inferred from Sequence Orthology
more info
 
miRNA binding ISO
Inferred from Sequence Orthology
more info
 
miRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
3'-UTR-mediated mRNA stabilization ISO
Inferred from Sequence Orthology
more info
 
3'-UTR-mediated mRNA stabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
mRNA stabilization ISO
Inferred from Sequence Orthology
more info
 
mRNA stabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of gene silencing by miRNA ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene silencing by miRNA ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of translation ISO
Inferred from Sequence Orthology
more info
 
protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
protein homooligomerization ISS
Inferred from Sequence or Structural Similarity
more info
 
protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
regulation of stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic stress granule ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynapse ISO
Inferred from Sequence Orthology
more info
 
ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 
ribonucleoprotein complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
ELAV-like protein 1
Names
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)
ELAV like 1
hu-antigen R
mRNA-stabilizing factor HuR

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108848.1NP_001102318.1  ELAV-like protein 1

    See identical proteins and their annotated locations for NP_001102318.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474084
    UniProtKB/Swiss-Prot
    B5DF91
    Related
    ENSRNOP00000001415.5, ENSRNOT00000001415.6
    Conserved Domains (1) summary
    TIGR01661
    Location:19326
    ELAV_HUD_SF; ELAV/HuD family splicing factor

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005111.4 Reference Rnor_6.0 Primary Assembly

    Range
    2461502..2502432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000080.1 Alternate Rn_Celera

    Range
    4459379..4500318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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