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Ube2l3 ubiquitin-conjugating enzyme E2L 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363836, updated on 5-Aug-2018

Summary

Official Symbol
Ube2l3provided by RGD
Official Full Name
ubiquitin-conjugating enzyme E2L 3provided by RGD
Primary source
RGD:1308361
See related
Ensembl:ENSRNOG00000001862
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
UbcH7; UbcR7
Expression
Biased expression in Thymus (RPKM 290.4), Kidney (RPKM 289.7) and 9 other tissues See more
Orthologs

Genomic context

See Ube2l3 in Genome Data Viewer
Location:
11q23
Exon count:
5
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (88047186..88088477)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 11 NC_005110.3 (91100202..91140629)

Chromosome 11 - NC_005110.4Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L37 pseudogene Neighboring gene RIMS binding protein 3 Neighboring gene coiled-coil domain containing 116 Neighboring gene YdjC chitooligosaccharide deacetylase homolog Neighboring gene stromal cell-derived factor 2-like 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

  • Parkinson's disease, organism-specific biosystem (from KEGG)
    Parkinson's disease, organism-specific biosystemParkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Mutations...
  • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
    Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
  • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
    Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
ubiquitin conjugating enzyme activity ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin-protein transferase activator activity ISO
Inferred from Sequence Orthology
more info
 
ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
brain development IEP
Inferred from Expression Pattern
more info
PubMed 
cell cycle phase transition ISO
Inferred from Sequence Orthology
more info
 
cell proliferation ISO
Inferred from Sequence Orthology
more info
 
cellular response to glucocorticoid stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to steroid hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
presynapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ubiquitin-conjugating enzyme E2 L3
NP_001316065.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329136.1NP_001316065.1  ubiquitin-conjugating enzyme E2 L3

    Status: VALIDATED

    Source sequence(s)
    AC128500
    UniProtKB/TrEMBL
    B2RZA9
    Conserved Domains (1) summary
    smart00212
    Location:6149
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005110.4 Reference Rnor_6.0 Primary Assembly

    Range
    88047186..88088477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000079.1 Alternate Rn_Celera

    Range
    82559953..82601068
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108847.1: Suppressed sequence

    Description
    NM_001108847.1: This RefSeq was removed because it was annotated with an incorrect coding sequence.
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