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HEM2 porphobilinogen synthase [ Candida albicans SC5314 ]

Gene ID: 3637428, updated on 30-Nov-2023

Summary

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Gene symbol
HEM2
Gene description
porphobilinogen synthase
Locus tag
CAALFM_C203300WA
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Candida albicans SC5314 (strain: SC5314, nat-host: Homo sapiens, culture-collection: ATCC:MYA-2876)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida
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Genomic context

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Location:
chromosome: 2
Exon count:
1
Sequence:
Chromosome: 2; NC_032090.1 (680927..681952)

Chromosome 2 - NC_032090.1Genomic Context describing neighboring genes Neighboring gene FG-nucleoporin Neighboring gene uncharacterized protein Neighboring gene ESCRT-III subunit protein Neighboring gene Chk1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_032090.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure. Muzzey D, et al. Genome Biol, 2013. PMID 24025428, Free PMC Article
  2. Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes. van het Hoog M, et al. Genome Biol, 2007. PMID 17419877, Free PMC Article
  3. The diploid genome sequence of Candida albicans. Jones T, et al. Proc Natl Acad Sci U S A, 2004 May 11. PMID 15123810, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables porphobilinogen synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in heme biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
porphobilinogen synthase
XP_721019.2
  • Putative porphobilinogen synthase; induced in high iron; protein level decrease in stationary phase cultures; Spider biofilm repressed

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_032090.1 Reference assembly

    Range
    680927..681952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_715926.2 → XP_721019.2  porphobilinogen synthase [Candida albicans SC5314]

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A1D8PGU4, C4YJS7
    Conserved Domains (1) summary
    cl00338
    Location:21 → 339
    ALAD_PBGS; Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the ...
Nucleotide Protein
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