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LIG1 tRNA ligase [ Candida albicans SC5314 ]

Gene ID: 3636947, updated on 16-Jun-2026
Gene symbol
LIG1
Gene description
tRNA ligase
Locus tag
CAALFM_C702060WA
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Candida albicans SC5314 (strain: SC5314, nat-host: Homo sapiens, culture-collection: ATCC:MYA-2876)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Pichiomycetes; Debaryomycetaceae; Candida/Lodderomyces clade; Candida
Orthologs
all
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See LIG1 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
1
Sequence:
Chromosome: 7; NC_032095.1 (458219..460717)

Chromosome 7 - NC_032095.1Genomic Context describing neighboring genes Neighboring gene transcription factor CUP9 Neighboring gene GTP-Rho binding exocyst subunit Neighboring gene uncharacterized protein Neighboring gene Grx1p

Genomic Sequence:
NC_032095.1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structural basis for the GTP specificity of the RNA kinase domain of fungal tRNA ligase. Remus BS, et al. Nucleic Acids Res, 2017 Dec 15. PMID 29165709, Free PMC Article
  2. Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure. Muzzey D, et al. Genome Biol, 2013. PMID 24025428, Free PMC Article
  3. Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes. van het Hoog M, et al. Genome Biol, 2007. PMID 17419877, Free PMC Article
  4. The diploid genome sequence of Candida albicans. Jones T, et al. Proc Natl Acad Sci U S A, 2004 May 11. PMID 15123810, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Findings suggest for the tRNA ligase as an antifungal target.
    Title: Structural basis for the GTP specificity of the RNA kinase domain of fungal tRNA ligase.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA ligase (ATP) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in tRNA splicing, via endonucleolytic cleavage and ligation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
tRNA ligase
XP_721349.1
  • tRNA ligase; functional homolog of S. cerevisiae Trl1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_032095.1 Reference assembly

    Range
    458219..460717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_716256.2 → XP_721349.1  tRNA ligase

    See identical proteins and their annotated locations for XP_721349.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    A0A1D8PR09, P43075, Q3MPD7, Q5AH27
    UniProtKB/TrEMBL
    C4YTR1
    Conserved Domains (4) summary
    COG5324
    Location:3 → 788
    Trl1; tRNA splicing ligase [Translation, ribosomal structure and biogenesis]
    pfam08302
    Location:590 → 782
    tRNA_lig_CPD; Fungal tRNA ligase phosphodiesterase domain
    pfam08303
    Location:414 → 581
    tRNA_lig_kinase; tRNA ligase kinase domain
    pfam09511
    Location:61 → 308
    RNA_lig_T4_1; RNA ligase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43075.2

Gene LinkOut

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Molecular Biology Databases
Research Materials