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Ccr10 C-C motif chemokine receptor 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363682, updated on 30-Jul-2025
Official Symbol
Ccr10provided by RGD
Official Full Name
C-C motif chemokine receptor 10provided by RGD
Primary source
RGD:1310716
See related
Ensembl:ENSRNOG00000020275 AllianceGenome:RGD:1310716
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gpr2
Summary
Predicted to enable C-C chemokine binding activity and C-C chemokine receptor activity. Predicted to be involved in several processes, including calcium-mediated signaling; cell chemotaxis; and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within chemotaxis. Predicted to be located in cell surface and endoplasmic reticulum. Predicted to be active in external side of plasma membrane. Orthologous to human CCR10 (C-C motif chemokine receptor 10). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Kidney (RPKM 68.9), Heart (RPKM 25.4) and 8 other tissues See more
Orthologs
human mouse all
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See Ccr10 in Genome Data Viewer
Location:
10q31
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (86608836..86611273, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (86108551..86110988, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (89086556..89088993, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene tubulin, gamma 2 Neighboring gene pleckstrin homology, MyTH4 and FERM domain containing H3 Neighboring gene contactin associated protein 1 Neighboring gene enhancer of zeste 1 polycomb repressive complex 2 subunit Neighboring gene uncharacterized LOC134480876 Neighboring gene uncharacterized LOC120095184

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine. Jarmin DI, et al. J Immunol, 2000 Apr 1. PMID 10725696
  2. Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). Wang W, et al. J Biol Chem, 2000 Jul 21. PMID 10781587
  3. CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow. Miles A, et al. Am J Physiol Gastrointest Liver Physiol, 2008 May. PMID 18308860
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables C-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables C-C chemokine receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables C-C chemokine receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables chemokine receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables chemokine receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
C-C chemokine receptor type 10
Names
G protein-coupled receptor 2
chemokine (C-C motif) receptor 10

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108836.1 → NP_001102306.1  C-C chemokine receptor type 10

    See identical proteins and their annotated locations for NP_001102306.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A6HJ92, D3ZJH1
    Related
    ENSRNOP00000027458.4, ENSRNOT00000027458.7
    Conserved Domains (1) summary
    cd15177
    Location:42 → 321
    7tmA_CCR10; CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    86608836..86611273 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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