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Cnot8 CCR4-NOT transcription complex, subunit 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363603, updated on 8-Apr-2026
Official Symbol
Cnot8provided by RGD
Official Full Name
CCR4-NOT transcription complex, subunit 8provided by RGD
Primary source
RGD:1306401
See related
Ensembl:ENSRNOG00000002630 AllianceGenome:RGD:1306401
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable poly(A)-specific ribonuclease activity. Predicted to be involved in miRNA-mediated gene silencing by mRNA destabilization and positive regulation of cell population proliferation. Predicted to be located in nucleus. Predicted to be part of CCR4-NOT complex. Orthologous to human CNOT8 (CCR4-NOT transcription complex subunit 8). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Thymus (RPKM 312.9), Spleen (RPKM 240.7) and 9 other tissues See more
Orthologs
all
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See Cnot8 in Genome Data Viewer
Location:
10q22
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (42782042..42795207)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (42281614..42294740)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (43538150..43551271)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene fatty acid hydroxylase domain containing 2 Neighboring gene uncharacterized LOC134480692 Neighboring gene transfer RNA serine (anticodon AGA) 43 Neighboring gene gem (nuclear organelle) associated protein 5 Neighboring gene mitochondrial ribosomal protein L22 Neighboring gene interferon gamma induced GTPase like 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation. Aslam A, et al. Mol Biol Cell, 2009 Sep. PMID 19605561, Free PMC Article
  2. Conservation of the deadenylase activity of proteins of the Caf1 family in human. Bianchin C, et al. RNA, 2005 Apr. PMID 15769875, Free PMC Article
  3. CCR4-NOT deadenylates mRNA associated with RNA-induced silencing complexes in human cells. Piao X, et al. Mol Cell Biol, 2010 Mar. PMID 20065043, Free PMC Article
  4. Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1. Bogdan JA, et al. Biochem J, 1998 Dec 1. PMID 9820826, Free PMC Article
  5. The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex. Petit AP, et al. Nucleic Acids Res, 2012 Nov. PMID 22977175, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Clone Names

  • MGC94581

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3'-5'-RNA exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables 3'-5'-RNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(A)-specific ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A)-specific ribonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables poly(A)-specific ribonuclease activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in miRNA-mediated gene silencing by mRNA destabilization IEA
Inferred from Electronic Annotation
more info
  
involved_in miRNA-mediated gene silencing by mRNA destabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mRNA catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of CCR4-NOT complex IEA
Inferred from Electronic Annotation
more info
  
part_of CCR4-NOT complex ISO
Inferred from Sequence Orthology
more info
  
part_of CCR4-NOT core complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
CCR4-NOT transcription complex subunit 8
NP_001008383.1
XP_006246454.1
XP_038942393.1
XP_063125577.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008382.1 → NP_001008383.1  CCR4-NOT transcription complex subunit 8

    See identical proteins and their annotated locations for NP_001008383.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085856
    UniProtKB/TrEMBL
    A6HEQ7, F7F1V4, Q5U2U9
    Conserved Domains (1) summary
    cl23804
    Location:1 → 263
    CAF1; CAF1 family ribonuclease

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    42782042..42795207
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086465.2 → XP_038942393.1  CCR4-NOT transcription complex subunit 8 isoform X1

    UniProtKB/TrEMBL
    A6HEQ7, F7F1V4, Q5U2U9
    Conserved Domains (1) summary
    cl23804
    Location:1 → 263
    CAF1; CAF1 family ribonuclease

  2. XM_006246392.5 → XP_006246454.1  CCR4-NOT transcription complex subunit 8 isoform X1

    See identical proteins and their annotated locations for XP_006246454.1

    UniProtKB/TrEMBL
    A6HEQ7, F7F1V4, Q5U2U9
    Conserved Domains (1) summary
    cl23804
    Location:1 → 263
    CAF1; CAF1 family ribonuclease

  3. XM_063269507.1 → XP_063125577.1  CCR4-NOT transcription complex subunit 8 isoform X1

    UniProtKB/TrEMBL
    A6HEQ7, F7F1V4, Q5U2U9
    Related
    ENSRNOP00000003555.3, ENSRNOT00000003555.6
Nucleotide Protein Strain
Heading Accession and Version

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