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Cav2 caveolin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363425, updated on 12-Jan-2022

Summary

Official Symbol
Cav2provided by RGD
Official Full Name
caveolin 2provided by RGD
Primary source
RGD:620348
See related
Ensembl:ENSRNOG00000057713
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables mitogen-activated protein kinase kinase kinase binding activity; phosphoprotein binding activity; and syntaxin binding activity. Involved in several processes, including insulin receptor signaling pathway; negative regulation of endothelial cell proliferation; and positive regulation of peptidyl-tyrosine phosphorylation. Located in several cellular components, including caveola; lipid droplet; and nuclear inner membrane. Part of protein-containing complex. Biomarker of high grade glioma and obesity. Human ortholog(s) of this gene implicated in low tension glaucoma and primary open angle glaucoma. Orthologous to human CAV2 (caveolin 2). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Lung (RPKM 1125.0), Heart (RPKM 413.6) and 7 other tissues See more
Orthologs
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Genomic context

See Cav2 in Genome Data Viewer
Location:
4q21
Exon count:
3
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (45616766..45624144)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (44573264..44580640)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene testin LIM domain protein Neighboring gene uncharacterized LOC102550644 Neighboring gene uncharacterized LOC120102239 Neighboring gene caveolin 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC72322

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables D1 dopamine receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables D1 dopamine receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables SNARE binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mitogen-activated protein kinase kinase kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-macromolecule adaptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables scaffold protein binding IEA
Inferred from Electronic Annotation
more info
 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
enables syntaxin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in basement membrane organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within basement membrane organization ISO
Inferred from Sequence Orthology
more info
 
involved_in caveola assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in caveola assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in caveola assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in caveola assembly ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in endoplasmic reticulum organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within endoplasmic reticulum organization ISO
Inferred from Sequence Orthology
more info
 
involved_in endoplasmic reticulum organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrion organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrion organization ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endothelial cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endothelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation by host of viral process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation by host of viral process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dopamine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of dopamine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dopamine receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein localization to nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in receptor-mediated endocytosis of virus by host cell IEA
Inferred from Electronic Annotation
more info
 
involved_in receptor-mediated endocytosis of virus by host cell ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
involved_in skeletal muscle fiber development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within skeletal muscle fiber development ISO
Inferred from Sequence Orthology
more info
 
involved_in skeletal muscle fiber development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in vesicle docking IEA
Inferred from Electronic Annotation
more info
 
involved_in vesicle docking ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle docking ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in vesicle fusion IEA
Inferred from Electronic Annotation
more info
 
involved_in vesicle fusion ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle fusion ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in vesicle organization ISO
Inferred from Sequence Orthology
more info
 
involved_in viral release from host cell IEA
Inferred from Electronic Annotation
more info
 
involved_in viral release from host cell ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in acrosomal membrane IEA
Inferred from Electronic Annotation
more info
 
located_in acrosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in caveola IDA
Inferred from Direct Assay
more info
PubMed 
located_in caveola ISO
Inferred from Sequence Orthology
more info
 
located_in caveola ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
part_of caveolar macromolecular signaling complex IEA
Inferred from Electronic Annotation
more info
 
part_of caveolar macromolecular signaling complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in extrinsic component of cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extrinsic component of cytoplasmic side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
colocalizes_with focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with focal adhesion ISO
Inferred from Sequence Orthology
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
located_in transport vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in transport vesicle ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131914.3NP_571989.3  caveolin-2

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000141
    Related
    ENSRNOP00000075024.1, ENSRNOT00000080271.2
    Conserved Domains (1) summary
    pfam01146
    Location:39160
    Caveolin

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    45616766..45624144
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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