U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ca12 carbonic anhydrase 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363085, updated on 5-Jul-2025
Official Symbol
Ca12provided by RGD
Official Full Name
carbonic anhydrase 12provided by RGD
Primary source
RGD:1306612
See related
Ensembl:ENSRNOG00000017766 AllianceGenome:RGD:1306612
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Car12
Summary
Predicted to enable carbonate dehydratase activity. Involved in estrous cycle. Located in apical plasma membrane and basolateral plasma membrane. Human ortholog(s) of this gene implicated in isolated hyperchlorhidrosis and lung non-small cell carcinoma. Orthologous to human CA12 (carbonic anhydrase 12). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Restricted expression toward (RPKM 2722.9) See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table
See Ca12 in Genome Data Viewer
Location:
8q24
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (76169723..76225465)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (67274739..67330428)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (72405770..72461425)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094375 Neighboring gene uncharacterized LOC134480068 Neighboring gene uncharacterized LOC120094191 Neighboring gene aph-1 homolog B, gamma secretase subunit like 2 Neighboring gene aph-1 homolog B, gamma secretase subunit like 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Integrative Proteo-Genomic Analysis for Recurrent Survival Prognosis in Colon Adenocarcinoma. Ai F, et al. Front Oncol, 2022. PMID 35847888, Free PMC Article
  2. The Role of the miR-548au-3p/CA12 Axis in Tracheal Chondrogenesis in Congenital Pulmonary Airway Malformations. Zeng J, et al. Oxid Med Cell Longev, 2023. PMID 36846718, Free PMC Article
  3. Prognostic value of carbonic anhydrase XII (CA XII) overexpression in hepatocellular carcinoma. Gu XF, et al. Int J Clin Exp Pathol, 2019. PMID 31934040, Free PMC Article
  4. Expression of carbonic anhydrases II, IV, VII, VIII and XII in rat brain after kainic acid induced status epilepticus. Halmi P, et al. Neurochem Int, 2006 Jan. PMID 16271802
  5. An inhibitory antibody targeting carbonic anhydrase XII abrogates chemoresistance and significantly reduces lung metastases in an orthotopic breast cancer model in vivo. von Neubeck B, et al. Int J Cancer, 2018 Oct 15. PMID 29786141

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Role of the miR-548au-3p/CA12 Axis in Tracheal Chondrogenesis in Congenital Pulmonary Airway Malformations.
    Title: The Role of the miR-548au-3p/CA12 Axis in Tracheal Chondrogenesis in Congenital Pulmonary Airway Malformations.
  2. binding of HIF-1alpha to select hypoxia-responsive elements on CA9/12 promoters, was observed.
    Title: Bicarbonate Recycling by HIF-1-Dependent Carbonic Anhydrase Isoforms 9 and 12 Is Critical in Maintaining Intracellular pH and Viability of Nucleus Pulposus Cells.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carbonate dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbonate dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables carbonate dehydratase activity ISO
Inferred from Sequence Orthology
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chloride ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in chloride ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in estrous cycle IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
carbonic anhydrase 12
Names
carbonic anyhydrase 12
membrane-bound carbonic anhydrase 12
NP_001074225.1
XP_006243373.1
XP_063121841.1
XP_063121842.1
XP_063121843.1
XP_063121844.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080756.2 → NP_001074225.1  carbonic anhydrase 12 precursor

    See identical proteins and their annotated locations for NP_001074225.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I6A5P9, A2IBE2
    Conserved Domains (1) summary
    cl00012
    Location:39 → 290
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    76169723..76225465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265771.1 → XP_063121841.1  carbonic anhydrase 12 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A5P9, F7FAJ9
    Related
    ENSRNOP00000023952.6, ENSRNOT00000023952.8

  2. XM_006243311.5 → XP_006243373.1  carbonic anhydrase 12 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A5P9, A0A8I6AH35
    Related
    ENSRNOP00000091938.1, ENSRNOT00000105264.2
    Conserved Domains (1) summary
    cl00012
    Location:39 → 290
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

  3. XM_063265772.1 → XP_063121842.1  carbonic anhydrase 12 isoform X3

    UniProtKB/TrEMBL
    A6J5I5

  4. XM_063265774.1 → XP_063121844.1  carbonic anhydrase 12 isoform X4

    UniProtKB/TrEMBL
    A6J5I4, A6J5I5

  5. XM_063265773.1 → XP_063121843.1  carbonic anhydrase 12 isoform X3

    UniProtKB/TrEMBL
    A6J5I5
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous