Stra6 signaling receptor and transporter of retinol STRA6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stra6provided by RGD
Official Full Name: signaling receptor and transporter of retinol STRA6provided by RGD
Primary source: RGD:1307551
See related: Ensembl:ENSRNOG00000008312 AllianceGenome:RGD:1307551
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1307551
Summary: Predicted to enable retinol transmembrane transporter activity. Involved in response to retinoic acid. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in syndromic microphthalmia 9. Orthologous to human STRA6 (signaling receptor and transporter of retinol STRA6). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Biased expression in Kidney (RPKM 90.1), Uterus (RPKM 21.2) and 2 other tissues See more
Orthologs: all
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Genomic context

Location:: 8q24

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (67444757..67464719)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (58548899..58568861)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (62925364..62944438)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

AI059311 (e-PCR)
- UniSTS:261647

BI284420 (e-PCR)
- UniSTS:244120

Stra6 (e-PCR), detects polymorphism
- UniSTS:516093

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables retinol transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables retinol transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables retinol transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adrenal gland development	ISO Inferred from Sequence Orthology more info
involved_in alveolar primary septum development	ISO Inferred from Sequence Orthology more info
involved_in artery morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in blood vessel development	ISO Inferred from Sequence Orthology more info
involved_in camera-type eye development	ISO Inferred from Sequence Orthology more info
involved_in camera-type eye development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cognition	ISO Inferred from Sequence Orthology more info
involved_in developmental growth	ISO Inferred from Sequence Orthology more info
involved_in diaphragm development	ISO Inferred from Sequence Orthology more info
involved_in digestive tract morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in ductus arteriosus closure	ISO Inferred from Sequence Orthology more info
involved_in ear development	ISO Inferred from Sequence Orthology more info
involved_in embryonic camera-type eye formation	ISO Inferred from Sequence Orthology more info
involved_in embryonic digestive tract development	ISO Inferred from Sequence Orthology more info
involved_in eyelid development in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in face morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in female genitalia development	ISO Inferred from Sequence Orthology more info
involved_in head development	ISO Inferred from Sequence Orthology more info
involved_in head morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in heart development	ISO Inferred from Sequence Orthology more info
involved_in kidney development	ISO Inferred from Sequence Orthology more info
involved_in learning	ISO Inferred from Sequence Orthology more info
involved_in lung alveolus development	ISO Inferred from Sequence Orthology more info
involved_in lung development	ISO Inferred from Sequence Orthology more info
involved_in lung vasculature development	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular process	ISO Inferred from Sequence Orthology more info
involved_in nose morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in paramesonephric duct development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in pulmonary artery morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in pulmonary valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within retinol transport	ISO Inferred from Sequence Orthology more info
involved_in retinol transport	ISO Inferred from Sequence Orthology more info
involved_in retinol transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in smooth muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in uterus morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in ventricular septum development	ISO Inferred from Sequence Orthology more info
involved_in vitamin A import into cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in vocal learning	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: receptor for retinol uptake STRA6

Names: retinol-binding protein receptor STRA6; stimulated by retinoic acid 6; stimulated by retinoic acid gene 6 homolog; stimulated by retinoic acid gene 6 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.