Sin3a SIN3 transcription regulator family member A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sin3aprovided by RGD
Official Full Name: SIN3 transcription regulator family member Aprovided by RGD
Primary source: RGD:1311598
See related: Ensembl:ENSRNOG00000032254 AllianceGenome:RGD:1311598
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables RNA binding activity. Involved in cellular response to dopamine; cellular response to tert-butyl hydroperoxide; and regulation of hormone levels. Located in chromatin and nucleus. Part of protein-containing complex. Used to study transient cerebral ischemia. Human ortholog(s) of this gene implicated in chromosome 15q24 deletion syndrome. Orthologous to human SIN3A (SIN3 transcription regulator family member A). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Thymus (RPKM 103.8), Adrenal (RPKM 99.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (66377471..66432150)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (57481539..57536195)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (61748590..61803314)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MeCP2 is an elongated monomer that does not stably associate with the Sin3a chromatin remodeling complex
Title: MeCP2 behaves as an elongated monomer that does not stably associate with the Sin3a chromatin remodeling complex.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables transcription regulator inhibitor activity	IEA Inferred from Electronic Annotation more info
enables transcription regulator inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA replication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA replication	ISO Inferred from Sequence Orthology more info
involved_in activation of innate immune response	IEA Inferred from Electronic Annotation more info
involved_in activation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in cellular response to dopamine	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tert-butyl hydroperoxide	IDA Inferred from Direct Assay more info	PubMed
involved_in cerebral cortex neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in cerebral cortex neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in heterochromatin formation	IEA Inferred from Electronic Annotation more info
involved_in heterochromatin formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular protein localization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular protein localization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of circadian rhythm	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to nucleus	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of G2/M transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of defense response to virus by host	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of axon extension	IEA Inferred from Electronic Annotation more info
involved_in regulation of axon extension	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of hormone levels	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to methylglyoxal	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to methylglyoxal	ISO Inferred from Sequence Orthology more info
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info
involved_in type I interferon-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Sin3-type complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Sin3-type complex	IEA Inferred from Electronic Annotation more info
part_of Sin3-type complex	ISO Inferred from Sequence Orthology more info
is_active_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
part_of histone deacetylase complex	IEA Inferred from Electronic Annotation more info
part_of histone deacetylase complex	ISO Inferred from Sequence Orthology more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info
part_of transcription repressor complex	IEA Inferred from Electronic Annotation more info
part_of transcription repressor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: paired amphipathic helix protein Sin3a

Names: SIN3 homolog A, transcription regulator; SIN3 transcription regulator homolog A; transcriptional regulator, SIN3A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395640.1 → NP_001382569.1 paired amphipathic helix protein Sin3a

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

D3ZBP2

Conserved Domains (1) summary

COG5602
Location:8 → 1214

Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

66377471..66432150

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008766301.4 → XP_008764523.1 paired amphipathic helix protein Sin3a isoform X1

See identical proteins and their annotated locations for XP_008764523.1

UniProtKB/TrEMBL

D3ZBP2

Related

ENSRNOP00000112788.1, ENSRNOT00000124949.1

Conserved Domains (1) summary

COG5602
Location:8 → 1214

Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
XM_063265753.1 → XP_063121823.1 paired amphipathic helix protein Sin3a isoform X1

UniProtKB/TrEMBL

D3ZBP2
XM_039081736.2 → XP_038937664.1 paired amphipathic helix protein Sin3a isoform X1

UniProtKB/TrEMBL

D3ZBP2

Conserved Domains (1) summary

COG5602
Location:8 → 1214

Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
XM_008766299.4 → XP_008764521.1 paired amphipathic helix protein Sin3a isoform X1

See identical proteins and their annotated locations for XP_008764521.1

UniProtKB/TrEMBL

D3ZBP2

Conserved Domains (1) summary

COG5602
Location:8 → 1214

Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
XM_039081735.2 → XP_038937663.1 paired amphipathic helix protein Sin3a isoform X1

UniProtKB/TrEMBL

D3ZBP2

Conserved Domains (1) summary

COG5602
Location:8 → 1214

Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
XM_008766302.4 → XP_008764524.1 paired amphipathic helix protein Sin3a isoform X1

See identical proteins and their annotated locations for XP_008764524.1

UniProtKB/TrEMBL

D3ZBP2

Conserved Domains (1) summary

COG5602
Location:8 → 1214

Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
XM_063265751.1 → XP_063121821.1 paired amphipathic helix protein Sin3a isoform X1

UniProtKB/TrEMBL

D3ZBP2
XM_039081737.2 → XP_038937665.1 paired amphipathic helix protein Sin3a isoform X1

UniProtKB/TrEMBL

D3ZBP2

Conserved Domains (1) summary

COG5602
Location:8 → 1214

Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
XM_039081734.2 → XP_038937662.1 paired amphipathic helix protein Sin3a isoform X1

UniProtKB/TrEMBL

D3ZBP2

Conserved Domains (1) summary

COG5602
Location:8 → 1214

Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
XM_006243129.5 → XP_006243191.1 paired amphipathic helix protein Sin3a isoform X1

See identical proteins and their annotated locations for XP_006243191.1

UniProtKB/TrEMBL

D3ZBP2

Conserved Domains (1) summary

COG5602
Location:8 → 1214

Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
XM_063265752.1 → XP_063121822.1 paired amphipathic helix protein Sin3a isoform X1

UniProtKB/TrEMBL

D3ZBP2
XM_063265750.1 → XP_063121820.1 paired amphipathic helix protein Sin3a isoform X1

UniProtKB/TrEMBL

D3ZBP2

Related

ENSRNOP00000055480.3, ENSRNOT00000058685.5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001108761.1: Suppressed sequence

Description

NM_001108761.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.