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Rangap1 RAN GTPase activating protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362965, updated on 19-Nov-2025
Official Symbol
Rangap1provided by RGD
Official Full Name
RAN GTPase activating protein 1provided by RGD
Primary source
RGD:1310380
See related
Ensembl:ENSRNOG00000031789 AllianceGenome:RGD:1310380
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables small GTPase binding activity and ubiquitin protein ligase binding activity. Involved in cellular response to vasopressin and response to axon injury. Located in several cellular components, including axon cytoplasm; cytoplasmic periphery of the nuclear pore complex; and mitotic spindle. Part of nuclear pore cytoplasmic filaments. Biomarker of sciatic neuropathy. Orthologous to human RANGAP1 (Ran GTPase activating protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Testes (RPKM 215.2), Brain (RPKM 146.0) and 9 other tissues See more
Orthologs
human mouse all
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See Rangap1 in Genome Data Viewer
Location:
7q34
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (115104820..115130564, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (113224695..113250441, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (122939266..122967178, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene L3MBTL histone methyl-lysine binding protein 2 Neighboring gene uncharacterized LOC120093698 Neighboring gene chondroadherin-like Neighboring gene zinc finger CCCH-type containing 7B Neighboring gene TEF transcription factor, PAR bZIP family member

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. The Ran GTPase-activating protein (RanGAP1) is critically involved in smooth muscle cell differentiation, proliferation and migration following vascular injury: implications for neointima formation and restenosis. Vorpahl M, et al. PLoS One, 2014. PMID 24988324, Free PMC Article
  2. RAN GTPase is an effector of the invasive/metastatic phenotype induced by osteopontin. Kurisetty VV, et al. Oncogene, 2008 Dec 4. PMID 18794800
  3. Vasopressin V1a receptor is required for nucleocytoplasmic transport of mineralocorticoid receptor. Hori K, et al. Am J Physiol Renal Physiol, 2012 Oct. PMID 22811487
  4. A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex. Matunis MJ, et al. J Cell Biol, 1996 Dec. PMID 8978815, Free PMC Article
  5. Localized regulation of axonal RanGTPase controls retrograde injury signaling in peripheral nerve. Yudin D, et al. Neuron, 2008 Jul 31. PMID 18667152, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RanGAP1 expression, neointima formation in rat carotid arteries was associated with a significant upregulation of RanGAP1 expression at 3 and 7 days after balloon injury.
    Title: The Ran GTPase-activating protein (RanGAP1) is critically involved in smooth muscle cell differentiation, proliferation and migration following vascular injury: implications for neointima formation and restenosis.
  2. identifies RAN as a novel effector of osteopontin-mediated malignant transformation
    Title: RAN GTPase is an effector of the invasive/metastatic phenotype induced by osteopontin.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to peptide hormone stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to vasopressin IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of protein export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear export IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear export ISO
Inferred from Sequence Orthology
more info
  
involved_in protein sumoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to axon injury IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of SUMO ligase complex ISO
Inferred from Sequence Orthology
more info
  
located_in aggresome ISO
Inferred from Sequence Orthology
more info
  
located_in axon cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic periphery of the nuclear pore complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear pore cytoplasmic filaments IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
ran GTPase-activating protein 1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001244855.1 → NP_001231784.1  ran GTPase-activating protein 1

    See identical proteins and their annotated locations for NP_001231784.1

    Status: VALIDATED

    Source sequence(s)
    BP492086, CA509531, CV126932, CX570737, DY317647, FQ217036
    UniProtKB/TrEMBL
    A0A8I6AMS6, A6HT14, F1MAA5
    Related
    ENSRNOP00000050029.6, ENSRNOT00000052098.7
    Conserved Domains (3) summary
    cd00116
    Location:21 → 358
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:51 → 81
    LRR_RI; leucine-rich repeat [structural motif]
    pfam07834
    Location:405 → 584
    RanGAP1_C; RanGAP1 C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    115104820..115130564 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242101.5 → XP_006242163.1  ran GTPase-activating protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006242163.1

    UniProtKB/TrEMBL
    A0A8I6AMS6, A6HT14, F1MAA5
    Conserved Domains (3) summary
    cd00116
    Location:21 → 358
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:51 → 81
    LRR_RI; leucine-rich repeat [structural motif]
    pfam07834
    Location:405 → 584
    RanGAP1_C; RanGAP1 C-terminal domain

  2. XM_006242100.5 → XP_006242162.1  ran GTPase-activating protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K5R3, F1MAA5
    Related
    ENSRNOP00000073525.2, ENSRNOT00000090208.3
    Conserved Domains (3) summary
    cd00116
    Location:69 → 406
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:99 → 129
    LRR_RI; leucine-rich repeat [structural motif]
    pfam07834
    Location:453 → 632
    RanGAP1_C; RanGAP1 C-terminal domain

  3. XM_039079597.2 → XP_038935525.1  ran GTPase-activating protein 1 isoform X3

    Related
    ENSRNOP00000094275.2, ENSRNOT00000106829.2
    Conserved Domains (3) summary
    cd00116
    Location:69 → 406
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:99 → 129
    LRR_RI; leucine-rich repeat [structural motif]
    pfam07834
    Location:452 → 507
    RanGAP1_C; RanGAP1 C-terminal domain

RNA

  1. XR_005486677.2 RNA Sequence

  2. XR_010053010.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001012199.1: Suppressed sequence

    Description
    NM_001012199.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version

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