jeb jelly belly [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: jebprovided by FlyBase
Official Full Name: jelly bellyprovided by FlyBase
Primary source: FLYBASE:FBgn0086677
Locus tag: Dmel_CG30040
See related: AllianceGenome:FB:FBgn0086677
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG13180; CG13182; CG30040; Dmel\CG30040; Jeb; l(2)k05644; l(2)SH0422
Summary: Enables receptor ligand activity and transmembrane receptor protein tyrosine kinase activator activity. Involved in several processes, including muscle cell fate specification; negative regulation of neuromuscular synaptic transmission; and nervous system development. Located in several cellular components, including cell surface; synaptic vesicle; and type I terminal bouton. Is expressed in several structures, including adult head; embryonic myoblast; embryonic/larval neuromuscular junction; eye photoreceptor cell; and tract. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 48E1-48E2; 2-66 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (12085194..12119340, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (7972699..8006845, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DamID transcriptional profiling identifies the Snail/Scratch transcription factor Kahuli as an Alk target in the Drosophila visceral mesoderm.
Title: DamID transcriptional profiling identifies the Snail/Scratch transcription factor Kahuli as an Alk target in the Drosophila visceral mesoderm.
Role of Lmd transcription factor in visceral mesoderm development in relationship to Jeb/Alk signal transduction. Alk signalling negatively regulates Lmd activity through the MAPK cascade resulting in a relocalisation of Lmd from nucleus to cytoplasm.
Title: Jeb/Alk signalling regulates the Lame duck GLI family transcription factor in the Drosophila visceral mesoderm.
Jeb is a novel negative regulator of neuromuscular transmission.
Title: Jelly Belly trans-synaptic signaling to anaplastic lymphoma kinase regulates neurotransmission strength and synapse architecture.
The ligand Jelly Belly (Jeb) activates the Drosophila Alk receptor tyrosine kinase (RTK) to drive PC12 cell differentiation, but is unable to activate the mouse ALK RTK.
Title: The ligand Jelly Belly (Jeb) activates the Drosophila Alk RTK to drive PC12 cell differentiation, but is unable to activate the mouse ALK RTK.
Alk is the receptor for Jeb in the developing visceral mesoderm, and Jeb binding stimulates an Alk-driven, extracellular signal-regulated kinase-mediated signalling pathway, resulting in the expression of duf needed for muscle fusion
Title: Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion.
localized Jeb activates Alk and the downstream Ras/mitogen-activated protein kinase cascade to specify a select group of visceral muscle precursors as muscle-patterning pioneers
Title: Jelly belly protein activates the receptor tyrosine kinase Alk to specify visceral muscle pioneers.
these findings suggest that Jeb/Alk signaling helps R-cell axons to shape their environment for target recognition.
Title: Anterograde Jelly belly and Alk receptor tyrosine kinase signaling mediates retinal axon targeting in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane receptor protein tyrosine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase activator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in compound eye photoreceptor development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm migration involved in gastrulation	TAS Traceable Author Statement more info	PubMed
involved_in muscle cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in visceral muscle development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in terminal bouton	IBA Inferred from Biological aspect of Ancestor more info
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed
located_in type Ib terminal bouton	IDA Inferred from Direct Assay more info	PubMed
located_in type Is terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: jelly belly

Names: CG30040-PA; CG30040-PB; jeb-PA; jeb-PB; jelly-belly; jellybelly; lethal (2) SH0422

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

12085194..12119340 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001273981.1 → NP_001260910.1 jelly belly, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260910.1

Status: REVIEWED

UniProtKB/TrEMBL

L0CP68, L0CQP4, L0CQQ5, Q95NU8, Q9V657

Conserved Domains (1) summary

cd00112
Location:499 → 532

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
NM_136882.3 → NP_610726.1 jelly belly, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_610726.1

Status: REVIEWED

UniProtKB/TrEMBL

L0CP68, L0CQP4, L0CQQ5, Q95NU8, Q9V657

Related

FBpp0087128

Conserved Domains (1) summary

cd00112
Location:499 → 532

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...