Emc2 ER membrane protein complex subunit 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Emc2provided by RGD
Official Full Name: ER membrane protein complex subunit 2provided by RGD
Primary source: RGD:1310430
See related: Ensembl:ENSRNOG00000005123 AllianceGenome:RGD:1310430
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ttc35; RGD1310430
Summary: Predicted to contribute to membrane insertase activity. Predicted to be involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Predicted to be located in endoplasmic reticulum membrane. Predicted to be extrinsic component of endoplasmic reticulum membrane. Predicted to be part of EMC complex. Orthologous to human EMC2 (ER membrane protein complex subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Heart (RPKM 380.8), Muscle (RPKM 316.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q31

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (76471899..76508866)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (74587196..74624163)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (82338639..82377389)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237156

D7Got56 (e-PCR)
- UniSTS:114397

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to membrane insertase activity	IEA Inferred from Electronic Annotation more info
contributes_to membrane insertase activity	ISO Inferred from Sequence Orthology more info
contributes_to membrane insertase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence	IEA Inferred from Electronic Annotation more info
involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence	ISO Inferred from Sequence Orthology more info
involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence	ISS Inferred from Sequence or Structural Similarity more info
involved_in tail-anchored membrane protein insertion into ER membrane	IEA Inferred from Electronic Annotation more info
involved_in tail-anchored membrane protein insertion into ER membrane	ISO Inferred from Sequence Orthology more info
involved_in tail-anchored membrane protein insertion into ER membrane	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of EMC complex	IBA Inferred from Biological aspect of Ancestor more info
part_of EMC complex	IEA Inferred from Electronic Annotation more info
part_of EMC complex	ISO Inferred from Sequence Orthology more info
part_of EMC complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in extrinsic component of endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in extrinsic component of endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in extrinsic component of endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ER membrane protein complex subunit 2

Names: TPR repeat protein 35; tetratricopeptide repeat domain 35; tetratricopeptide repeat protein 35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113785.1 → NP_001107257.1 ER membrane protein complex subunit 2

See identical proteins and their annotated locations for NP_001107257.1

Status: PROVISIONAL

Source sequence(s)

BC158805

UniProtKB/Swiss-Prot

B0BNG0

UniProtKB/TrEMBL

A0A8I5ZZJ5, A6HRA5

Related

ENSRNOP00000088541.1, ENSRNOT00000115694.2

Conserved Domains (4) summary

sd00006
Location:120 → 150

TPR; TPR repeat [structural motif]

pfam13414
Location:156 → 222

TPR_11; TPR repeat

pfam13432
Location:62 → 121

TPR_16; Tetratricopeptide repeat

pfam14559
Location:99 → 164

TPR_19; Tetratricopeptide repeat