U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

rho-7 rhomboid-7 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36281, updated on 9-Jun-2025
Official Symbol
rho-7provided by FlyBase
Official Full Name
rhomboid-7provided by FlyBase
Primary source
FLYBASE:FBgn0033672
Locus tag
Dmel_CG8972
See related
AllianceGenome:FB:FBgn0033672
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0138581.3; CG8972; Dmel\CG8972; PARL; R7; Rho-7; Rhomboid-7
Summary
Enables endopeptidase activity. Involved in mitochondrial fusion and protein processing. Located in mitochondrion. Is expressed in adult head; embryonic/larval midgut; larval muscle system; and organism. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; coronary artery disease; hyperinsulinism; myopia; and type 2 diabetes mellitus. Orthologous to human PARL (presenilin associated rhomboid like). [provided by Alliance of Genome Resources, Jun 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table
See rho-7 in Genome Data Viewer
Location:
48D5-48D5; 2-65 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11986513..11988787, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7874018..7876292, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene beta1,3-galactosyltransferase 1 Neighboring gene Ribonucleoside diphosphate reductase small subunit Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45319 Neighboring gene long non-coding RNA:CR45318

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Rhomboid-7 over-expression results in Opa1-like processing and malfunctioning mitochondria. Rahman M, et al. Biochem Biophys Res Commun, 2011 Oct 22. PMID 21945938
  2. Regulation of mitochondrial inner membrane fusion: divergent evolution with similar solutions? Wagener J. Curr Genet, 2016 May. PMID 26613727
  3. Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin. Whitworth AJ, et al. Dis Model Mech, 2008 Sep-Oct. PMID 19048081, Free PMC Article
  4. Normal mitochondrial dynamics requires rhomboid-7 and affects Drosophila lifespan and neuronal function. McQuibban GA, et al. Curr Biol, 2006 May 23. PMID 16713954
  5. PARL: The mitochondrial rhomboid protease. Spinazzi M, et al. Semin Cell Dev Biol, 2016 Dec. PMID 27502471

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitochondrion organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of protein targeting to mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in signal peptide processing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
rhomboid-7
Names
CG8972-PA
CG8972-PB
Rhomboid-7
rho-7-PA
rho-7-PB
NP_001286324.1
NP_523704.1

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    11986513..11988787 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299395.1 → NP_001286324.1  rhomboid-7, isoform B

    See identical proteins and their annotated locations for NP_001286324.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1Z8R8, Q8MQY3
    Conserved Domains (1) summary
    pfam01694
    Location:186 → 327
    Rhomboid; Rhomboid family

  2. NM_078980.4 → NP_523704.1  rhomboid-7, isoform A

    See identical proteins and their annotated locations for NP_523704.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1Z8R8, Q8MQY3
    Related
    FBpp0087151
    Conserved Domains (1) summary
    pfam01694
    Location:186 → 327
    Rhomboid; Rhomboid family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z8R8.1 A1Z8R8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools