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Inf2 inverted formin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362790, updated on 13-Apr-2024

Summary

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Official Symbol
Inf2provided by RGD
Official Full Name
inverted formin 2provided by RGD
Primary source
RGD:1308350
See related
Ensembl:ENSRNOG00000028650 AllianceGenome:RGD:1308350
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308350
Summary
Predicted to enable actin binding activity and small GTPase binding activity. Predicted to be involved in actin cytoskeleton organization. Predicted to act upstream of or within regulation of cellular component size and regulation of mitochondrial fission. Predicted to be located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate E and focal segmental glomerulosclerosis 5. Orthologous to human INF2 (inverted formin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 61.1), Adrenal (RPKM 44.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
6q32
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (137470259..137497039)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (131649162..131675944)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (137162593..137180198)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 14 open reading frame 180 Neighboring gene transmembrane protein 179 Neighboring gene uncharacterized LOC102552388 Neighboring gene adenylosuccinate synthase 1 Neighboring gene SIVA1, apoptosis-inducing factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mutations in the formin gene INF2 cause focal segmental glomerulosclerosis. Brown EJ, et al. Nat Genet, 2010 Jan. PMID 20023659, Free PMC Article
  2. An actin-dependent step in mitochondrial fission mediated by the ER-associated formin INF2. Korobova F, et al. Science, 2013 Jan 25. PMID 23349293, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within actin nucleation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cellular component size ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of mitochondrial fission ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
inverted formin-2
Names
inverted formin, FH2 and WH2 domain containing

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427264.1 → NP_001414193.1  inverted formin-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  2. NM_001427265.1 → NP_001414194.1  inverted formin-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    137470259..137497039
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262154.1 → XP_063118224.1  inverted formin-2 isoform X5

    UniProtKB/TrEMBL
    E9PT22

  2. XM_039113407.2 → XP_038969335.1  inverted formin-2 isoform X6

    Conserved Domains (3) summary
    pfam06367
    Location:181 → 366
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:24 → 177
    Drf_GBD; Diaphanous GTPase-binding Domain
    cl19758
    Location:603 → 759
    FH2; Formin Homology 2 Domain

  3. XM_039113404.2 → XP_038969332.1  inverted formin-2 isoform X4

    Conserved Domains (5) summary
    PRK07764
    Location:1030 → 1217
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam06367
    Location:181 → 366
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:24 → 177
    Drf_GBD; Diaphanous GTPase-binding Domain
    cd22061
    Location:1013 → 1042
    WH2_INF2; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Inverted formin-2 (INF2)
    cl19758
    Location:603 → 967
    FH2; Formin Homology 2 Domain

  4. XM_063262150.1 → XP_063118220.1  inverted formin-2 isoform X1

  5. XM_039113400.2 → XP_038969328.1  inverted formin-2 isoform X1

    Conserved Domains (5) summary
    PRK07764
    Location:1030 → 1217
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam06367
    Location:181 → 366
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:24 → 177
    Drf_GBD; Diaphanous GTPase-binding Domain
    cd22061
    Location:1013 → 1042
    WH2_INF2; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Inverted formin-2 (INF2)
    cl19758
    Location:603 → 967
    FH2; Formin Homology 2 Domain

  6. XM_063262151.1 → XP_063118221.1  inverted formin-2 isoform X2

  7. XM_039113401.2 → XP_038969329.1  inverted formin-2 isoform X2

    Conserved Domains (5) summary
    PRK07764
    Location:1030 → 1217
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam06367
    Location:181 → 366
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:24 → 177
    Drf_GBD; Diaphanous GTPase-binding Domain
    cd22061
    Location:1013 → 1042
    WH2_INF2; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Inverted formin-2 (INF2)
    cl19758
    Location:603 → 967
    FH2; Formin Homology 2 Domain

  8. XM_063262152.1 → XP_063118222.1  inverted formin-2 isoform X3

  9. XM_063262153.1 → XP_063118223.1  inverted formin-2 isoform X3

RNA

  1. XR_005506360.2 RNA Sequence

  2. XR_005506355.2 RNA Sequence

  3. XR_005506354.2 RNA Sequence

  4. XR_005506356.2 RNA Sequence

  5. XR_005506358.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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