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Vrk1 VRK serine/threonine kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362779, updated on 28-Aug-2018

Summary

Official Symbol
Vrk1provided by RGD
Official Full Name
VRK serine/threonine kinase 1provided by RGD
Primary source
RGD:1306069
See related
Ensembl:ENSRNOG00000005274
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Thymus (RPKM 248.1), Spleen (RPKM 157.2) and 9 other tissues See more
Orthologs

Genomic context

See Vrk1 in Genome Data Viewer
Location:
6q32
Exon count:
14
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (129835788..129902839)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 6 NC_005105.3 (139031607..139098569)

Chromosome 6 - NC_005105.4Genomic Context describing neighboring genes Neighboring gene poly (A) polymerase alpha Neighboring gene uncharacterized LOC102551116 Neighboring gene uncharacterized LOC108351297 Neighboring gene uncharacterized LOC102551214 Neighboring gene uncharacterized LOC102554026

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
histone kinase activity (H3-S10 specific) IEA
Inferred from Electronic Annotation
more info
 
histone kinase activity (H3-S10 specific) ISO
Inferred from Sequence Orthology
more info
 
histone kinase activity (H3-T3 specific) IEA
Inferred from Electronic Annotation
more info
 
histone kinase activity (H3-T3 specific) ISO
Inferred from Sequence Orthology
more info
 
nucleosomal histone binding IEA
Inferred from Electronic Annotation
more info
 
nucleosomal histone binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Golgi disassembly IEA
Inferred from Electronic Annotation
more info
 
Golgi disassembly ISO
Inferred from Sequence Orthology
more info
 
histone H3-S10 phosphorylation IEA
Inferred from Electronic Annotation
more info
 
histone H3-S10 phosphorylation ISO
Inferred from Sequence Orthology
more info
 
histone H3-T3 phosphorylation IEA
Inferred from Electronic Annotation
more info
 
histone H3-T3 phosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi stack IEA
Inferred from Electronic Annotation
more info
 
Golgi stack ISO
Inferred from Sequence Orthology
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase VRK1
Names
vaccinia related kinase 1
NP_001012194.1
XP_006240592.1
XP_006240593.1
XP_006240594.1
XP_006240595.1
XP_008763044.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012194.1NP_001012194.1  serine/threonine-protein kinase VRK1

    See identical proteins and their annotated locations for NP_001012194.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079130
    UniProtKB/TrEMBL
    Q6AYA2
    Related
    ENSRNOP00000029546.4, ENSRNOT00000036035.4
    Conserved Domains (2) summary
    smart00220
    Location:37290
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14122
    Location:26326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005105.4 Reference Rnor_6.0 Primary Assembly

    Range
    129835788..129902839
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008764822.1XP_008763044.1  serine/threonine-protein kinase VRK1 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:37290
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14122
    Location:26326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
  2. XM_006240530.3XP_006240592.1  serine/threonine-protein kinase VRK1 isoform X1

    See identical proteins and their annotated locations for XP_006240592.1

    UniProtKB/TrEMBL
    Q6AYA2
    Conserved Domains (2) summary
    smart00220
    Location:37290
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14122
    Location:26326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
  3. XM_006240531.3XP_006240593.1  serine/threonine-protein kinase VRK1 isoform X1

    See identical proteins and their annotated locations for XP_006240593.1

    UniProtKB/TrEMBL
    Q6AYA2
    Conserved Domains (2) summary
    smart00220
    Location:37290
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14122
    Location:26326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
  4. XM_006240532.3XP_006240594.1  serine/threonine-protein kinase VRK1 isoform X1

    See identical proteins and their annotated locations for XP_006240594.1

    UniProtKB/TrEMBL
    Q6AYA2
    Conserved Domains (2) summary
    smart00220
    Location:37290
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14122
    Location:26326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
  5. XM_006240533.3XP_006240595.1  serine/threonine-protein kinase VRK1 isoform X1

    See identical proteins and their annotated locations for XP_006240595.1

    UniProtKB/TrEMBL
    Q6AYA2
    Conserved Domains (2) summary
    smart00220
    Location:37290
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14122
    Location:26326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

Alternate Rn_Celera

Genomic

  1. AC_000074.1 Alternate Rn_Celera

    Range
    122475358..122561934
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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