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Rrm2 ribonucleotide reductase regulatory subunit M2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362720, updated on 27-Nov-2020

Summary

Official Symbol
Rrm2provided by RGD
Official Full Name
ribonucleotide reductase regulatory subunit M2provided by RGD
Primary source
RGD:1598310
See related
Ensembl:ENSRNOG00000054286
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
putative ribonucleotide reductase enzyme; human homolog is required for formation of deoxyribonucleotides from ribonucleotides [RGD, Feb 2006]
Expression
Biased expression in Thymus (RPKM 533.8), Spleen (RPKM 381.5) and 6 other tissues See more
Orthologs

Genomic context

See Rrm2 in Genome Data Viewer
Location:
6q16
Exon count:
9
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (43884627..43890818)
106 current Rn_Celera (GCF_000002265.2) 6 AC_000074.1 (40627438..40633641)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 6 NC_005105.3 (60756160..60762351)

Chromosome 6 - NC_005105.4Genomic Context describing neighboring genes Neighboring gene Kruppel-like factor 11 Neighboring gene cystin 1 Neighboring gene skin secretory protein xP2-like Neighboring gene membrane bound O-acyltransferase domain containing 2 Neighboring gene serine palmitoyltransferase small subunit A pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Homology

  • Homologs of the Rrm2 gene: The Rrm2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs from Annotation Pipeline: 293 organisms have orthologs with human gene Rrm2
  • Orthologs

Clone Names

  • MGC116120

Gene Ontology Provided by RGD

Process Evidence Code Pubs
DNA replication IEA
Inferred from Electronic Annotation
more info
 
blastocyst development ISO
Inferred from Sequence Orthology
more info
 
deoxyribonucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
deoxyribonucleotide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
deoxyribonucleotide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
deoxyribonucleotide metabolic process ISO
Inferred from Sequence Orthology
more info
 
mitotic cell cycle IEP
Inferred from Expression Pattern
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein heterotetramerization ISO
Inferred from Sequence Orthology
more info
 
pyrimidine nucleobase metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
ribonucleoside-diphosphate reductase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ribonucleoside-diphosphate reductase subunit M2
Names
Ribonucleotide reductase 2
ribonucleotide reductase M2 polypeptide
ribonucleotide reductase small chain
ribonucleotide reductase small subunit
NP_001020911.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025740.2NP_001020911.1  ribonucleoside-diphosphate reductase subunit M2

    See identical proteins and their annotated locations for NP_001020911.1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000164
    UniProtKB/Swiss-Prot
    Q4KLN6
    Related
    ENSRNOP00000073334.1, ENSRNOT00000091551.1
    Conserved Domains (1) summary
    PLN02492
    Location:71390
    PLN02492; ribonucleoside-diphosphate reductase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005105.4 Reference Rnor_6.0 Primary Assembly

    Range
    43884627..43890818
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000074.1 Alternate Rn_Celera

    Range
    40627438..40633641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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