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Selenoi selenoprotein I [ Rattus norvegicus (Norway rat) ]

Gene ID: 362713, updated on 17-Nov-2020

Summary

Official Symbol
Selenoiprovided by RGD
Official Full Name
selenoprotein Iprovided by RGD
Primary source
RGD:1560938
See related
Ensembl:ENSRNOG00000059295
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ept1; Seli; RGD1560938
Summary
The multi-pass transmembrane protein encoded by this gene belongs to the CDP-alcohol phosphatidyltransferase class-I family. It catalyzes the transfer of phosphoethanolamine from CDP-ethanolamine to diacylglycerol to produce phosphatidylethanolamine, which is involved in the formation and maintenance of vesicular membranes, regulation of lipid metabolism, and protein folding. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2016]
Expression
Biased expression in Liver (RPKM 218.7), Brain (RPKM 182.3) and 9 other tissues See more
Orthologs

Genomic context

See Selenoi in Genome Data Viewer
Location:
6q14
Exon count:
10
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (27473748..27512287, complement)
106 current Rn_Celera (GCF_000002265.2) 6 AC_000074.1 (25550258..25588218, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 6 NC_005105.3 (37285872..37323978, complement)

Chromosome 6 - NC_005105.4Genomic Context describing neighboring genes Neighboring gene otoferlin Neighboring gene dynein regulatory complex subunit 1 Neighboring gene adhesion G protein-coupled receptor F3 Neighboring gene hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC188326

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ethanolaminephosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ethanolaminephosphotransferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
phosphatidylethanolamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylethanolamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ethanolaminephosphotransferase 1
Names
ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
NP_001128226.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134754.1NP_001128226.2  ethanolaminephosphotransferase 1

    Status: REVIEWED

    Source sequence(s)
    BC168235
    UniProtKB/TrEMBL
    B4F7D7
    Related
    ENSRNOP00000069055.1, ENSRNOT00000081278.1
    Conserved Domains (1) summary
    cl00453
    Location:6312
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005105.4 Reference Rnor_6.0 Primary Assembly

    Range
    27473748..27512287 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000074.1 Alternate Rn_Celera

    Range
    25550258..25588218 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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