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Damm Death associated molecule related to Mch2 caspase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36266, updated on 5-Jan-2022

Summary

Official Symbol
Dammprovided by FlyBase
Official Full Name
Death associated molecule related to Mch2 caspaseprovided by FlyBase
Primary source
FLYBASE:FBgn0033659
Locus tag
Dmel_CG18188
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG18188; damm; DAMM; Damm/Daydream; Daydream; Dmel\CG18188
Summary
Enables cysteine-type endopeptidase activity. Involved in apoptotic process and proteolysis. Predicted to be active in cytoplasm. Is expressed in several structures, including egg chamber; embryonic/larval central nervous system; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in ovarian carcinoma. Orthologous to human CASP6 (caspase 6). [provided by Alliance of Genome Resources, Nov 2021]
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Genomic context

See Damm in Genome Data Viewer
Location:
48C5-48C5; 2-65 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11864112..11866383, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7752681..7753888, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Tweedlebeta Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in programmed cell death IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in programmed cell death TAS
Traceable Author Statement
more info
PubMed 
involved_in proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
death associated molecule related to Mch2 caspase
Names
CG18188-PA
CG18188-PB
Damm-PA
Damm-PB
daydream
death associated molecule related to Mch2
NP_001303345.1
NP_523703.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    11864112..11866383 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001316416.1NP_001303345.1  death associated molecule related to Mch2 caspase, isoform B [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KHI6
    Related
    FBpp0312445, FBtr0347012
    Conserved Domains (1) summary
    pfam00656
    Location:42248
    Peptidase_C14; Caspase domain
  2. NM_078979.3NP_523703.2  death associated molecule related to Mch2 caspase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523703.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KHI6
    Related
    FBpp0087167, FBtr0088061
    Conserved Domains (1) summary
    pfam00656
    Location:42248
    Peptidase_C14; Caspase domain
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