Format

Send to:

Choose Destination

INHBC inhibin subunit beta C [ Homo sapiens (human) ]

Gene ID: 3626, updated on 11-Jun-2021

Summary

Official Symbol
INHBCprovided by HGNC
Official Full Name
inhibin subunit beta Cprovided by HGNC
Primary source
HGNC:HGNC:6068
See related
Ensembl:ENSG00000175189 MIM:601233
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IHBC
Summary
This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of homodimeric and heterodimeric activin complexes. The heterodimeric complex may function in the inhibition of activin A signaling. Transgenic mice overexpressing this gene exhibit defects in testis, liver and prostate. [provided by RefSeq, Aug 2016]
Expression
Restricted expression toward liver (RPKM 50.2) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See INHBC in Genome Data Viewer
Location:
12q13.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (57434784..57452062)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (57828567..57845845)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene SH3 and cysteine rich domain 3 Neighboring gene R3H domain containing 2 Neighboring gene RNA, U6 small nuclear 879, pseudogene Neighboring gene Sharpr-MPRA regulatory region 358 Neighboring gene inhibin subunit beta E

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
GeneReviews: Not available
Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
enables transforming growth factor beta receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of pathway-restricted SMAD protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
inhibin beta C chain
Names
activin beta-C chain
inhibin beta C subunit

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005538.4NP_005529.1  inhibin beta C chain preproprotein

    See identical proteins and their annotated locations for NP_005529.1

    Status: REVIEWED

    Source sequence(s)
    AC022506, BC130324, BP237373, BX105206
    Consensus CDS
    CCDS8938.1
    UniProtKB/Swiss-Prot
    P55103
    Related
    ENSP00000308716.2, ENST00000309668.3
    Conserved Domains (1) summary
    smart00204
    Location:247352
    TGFB; Transforming growth factor-beta (TGF-beta) family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    57434784..57452062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center