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INHBA inhibin subunit beta A [ Homo sapiens (human) ]

Gene ID: 3624, updated on 28-Oct-2019

Summary

Official Symbol
INHBAprovided by HGNC
Official Full Name
inhibin subunit beta Aprovided by HGNC
Primary source
HGNC:HGNC:6066
See related
Ensembl:ENSG00000122641 MIM:147290
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EDF; FRP
Summary
This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Elevated expression of this gene may be associated with cancer cachexia in human patients. [provided by RefSeq, Aug 2016]
Expression
Broad expression in endometrium (RPKM 12.3), gall bladder (RPKM 11.3) and 15 other tissues See more
Orthologs

Genomic context

See INHBA in Genome Data Viewer
Location:
7p14.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (41685101..41710532, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (41728601..41742706, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375247 Neighboring gene uncharacterized LOC107986789 Neighboring gene INHBA antisense RNA 1 Neighboring gene uncharacterized LOC107986788 Neighboring gene uncharacterized LOC105375248

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
NHGRI GWA Catalog
Genome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment.
NHGRI GWA Catalog
Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
NHGRI GWA Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
NHGRI GWA Catalog
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of inhibin, beta A (INHBA) in human B cells PubMed
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of inhibin, beta A (INHBA) in peptide-treated PBMCs PubMed
Tat tat HIV-1 Tat upregulates the expression of inhibin, beta A (INHBA) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • ALK1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
    ALK1 signaling events, organism-specific biosystem
    ALK1 signaling events
  • Activin signaling, organism-specific biosystem (from KEGG)
    Activin signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • Activin signaling, conserved biosystem (from KEGG)
    Activin signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • Antagonism of Activin by Follistatin, organism-specific biosystem (from REACTOME)
    Antagonism of Activin by Follistatin, organism-specific biosystemBoth Follistatin (FST) and Follistatin-like-3 (FSTL3) irreversibly bind Activin dimers and prevent Activin from interacting with its receptor (reviewed in Schneyer et al. 2004 ,Xia and Schneyer 2009)...
  • Cardiac Progenitor Differentiation, organism-specific biosystem (from WikiPathways)
    Cardiac Progenitor Differentiation, organism-specific biosystemFactors involved in the induction of cardiac differentiation in vitro and in vivo. This model was based on the below two review articles.
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Differentiation Pathway, organism-specific biosystem (from WikiPathways)
    Differentiation Pathway, organism-specific biosystemThis pathway provides an overview of the directed differentiation molecules used to induce early and derivative cell lineages from human pluripotent stem cells. The initial version of this pathway is...
  • Glycoprotein hormones, organism-specific biosystem (from REACTOME)
    Glycoprotein hormones, organism-specific biosystemMore complex protein hormones have carbohydrate side chains and are called glycoprotein hormones. Hormones in this class are Follicle-stimulating hormone (FSH; follitropin), Luteinizing hormone (LH),...
  • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
  • Mesodermal Commitment Pathway, organism-specific biosystem (from WikiPathways)
    Mesodermal Commitment Pathway, organism-specific biosystemModel depicting mesodermal specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell l...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Peptide hormone biosynthesis, organism-specific biosystem (from REACTOME)
    Peptide hormone biosynthesis, organism-specific biosystemPeptide hormones are peptides that are secreted directly into the blood stream (endocrine hormones). They are synthesized as precursors that require proteolytic processing (not discussed here) to gen...
  • Peptide hormone metabolism, organism-specific biosystem (from REACTOME)
    Peptide hormone metabolism, organism-specific biosystemPeptide hormones are cleaved from larger precursors in the secretory system (endoplasmic reticulum, Golgi apparatus, secretory granules) of the cell. After secretion peptide hormones are modified and...
  • Senescence and Autophagy in Cancer, organism-specific biosystem (from WikiPathways)
    Senescence and Autophagy in Cancer, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Activin, organism-specific biosystem (from REACTOME)
    Signaling by Activin, organism-specific biosystemActivin was initially discovered as an activator of follicle stimulating hormone in the pituitary gland. It has since been shown to be an important participant in the differentiation of embryonic cel...
  • Signaling pathways regulating pluripotency of stem cells, organism-specific biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, organism-specific biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
  • Signaling pathways regulating pluripotency of stem cells, conserved biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, conserved biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
  • TGF-beta Receptor Signaling, organism-specific biosystem (from WikiPathways)
    TGF-beta Receptor Signaling, organism-specific biosystemThe Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiat...
  • TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
    TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
  • TGF-beta signaling pathway, conserved biosystem (from KEGG)
    TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • AC005027.3

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
growth factor activity TAS
Traceable Author Statement
more info
PubMed 
hormone activity TAS
Traceable Author Statement
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
inhibin binding IEA
Inferred from Electronic Annotation
more info
 
peptide hormone binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
type II activin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
GABAergic neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
cell development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell differentiation TAS
Traceable Author Statement
more info
PubMed 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
cellular response to cholesterol IEA
Inferred from Electronic Annotation
more info
 
cellular response to follicle-stimulating hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
defense response TAS
Traceable Author Statement
more info
PubMed 
endodermal cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
erythrocyte differentiation NAS
Non-traceable Author Statement
more info
PubMed 
extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
eyelid development in camera-type eye ISS
Inferred from Sequence or Structural Similarity
more info
 
hair follicle development IGI
Inferred from Genetic Interaction
more info
PubMed 
hematopoietic progenitor cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
hemoglobin biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
male gonad development IGI
Inferred from Genetic Interaction
more info
PubMed 
mesodermal cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of B cell differentiation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of follicle-stimulating hormone secretion NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of interferon-gamma biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of macrophage differentiation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of phosphorylation TAS
Traceable Author Statement
more info
PubMed 
nervous system development NAS
Non-traceable Author Statement
more info
PubMed 
odontogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
ovarian follicle development IGI
Inferred from Genetic Interaction
more info
PubMed 
ovarian follicle development NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of cellular protein metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of erythrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of follicle-stimulating hormone secretion TAS
Traceable Author Statement
more info
PubMed 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ovulation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of pathway-restricted SMAD protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of pathway-restricted SMAD protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
progesterone secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of follicle-stimulating hormone secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
response to drug IDA
Inferred from Direct Assay
more info
PubMed 
NOT response to wounding TAS
Traceable Author Statement
more info
PubMed 
roof of mouth development IGI
Inferred from Genetic Interaction
more info
PubMed 
striatal medium spiny neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
activin A complex IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inhibin A complex IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
inhibin beta A chain
Names
FSH-releasing protein
Inhibin, beta-1
activin beta-A chain
erythroid differentiation factor
erythroid differentiation protein
follicle-stimulating hormone-releasing protein
inhibin beta A subunit
inhibin, beta A (activin A, activin AB alpha polypeptide)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002192.4NP_002183.1  inhibin beta A chain preproprotein

    See identical proteins and their annotated locations for NP_002183.1

    Status: REVIEWED

    Source sequence(s)
    AA491465, AC005027, AK001903, AU137531, BC007858
    Consensus CDS
    CCDS5464.1
    UniProtKB/Swiss-Prot
    P08476
    UniProtKB/TrEMBL
    A4D1W7
    Related
    ENSP00000242208.4, ENST00000242208.5
    Conserved Domains (2) summary
    smart00204
    Location:321426
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:56238
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    41685101..41710532 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012175.1XP_016867664.1  inhibin beta A chain isoform X2

  2. XM_017012176.1XP_016867665.1  inhibin beta A chain isoform X3

    UniProtKB/Swiss-Prot
    P08476
    UniProtKB/TrEMBL
    A4D1W7
    Conserved Domains (2) summary
    smart00204
    Location:321426
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:56238
    TGFb_propeptide; TGF-beta propeptide
  3. XM_017012174.1XP_016867663.1  inhibin beta A chain isoform X1

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