Rpia ribose 5-phosphate isomerase A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rpiaprovided by RGD
Official Full Name: ribose 5-phosphate isomerase Aprovided by RGD
Primary source: RGD:1311377
See related: Ensembl:ENSRNOG00000005576 AllianceGenome:RGD:1311377
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables monosaccharide binding activity and ribose-5-phosphate isomerase activity. Involved in pentose-phosphate shunt, non-oxidative branch. Predicted to be located in mitochondrion. Predicted to be active in cytosol. Orthologous to human RPIA (ribose 5-phosphate isomerase A). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Spleen (RPKM 188.8), Thymus (RPKM 159.1) and 9 other tissues See more
Orthologs: all
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Genomic context

Location:: 4q32

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (104282081..104307732, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (102723712..102749374, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (98568028..98593664, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH129819 (e-PCR)
- UniSTS:213108

RPIA (e-PCR)
- UniSTS:505025

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carbohydrate binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables monosaccharide binding	IDA Inferred from Direct Assay more info	PubMed
enables ribose-5-phosphate isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribose-5-phosphate isomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables ribose-5-phosphate isomerase activity	IEA Inferred from Electronic Annotation more info
enables ribose-5-phosphate isomerase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in D-ribose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pentose-phosphate shunt	IDA Inferred from Direct Assay more info	PubMed
involved_in pentose-phosphate shunt	IEA Inferred from Electronic Annotation more info
involved_in pentose-phosphate shunt	ISO Inferred from Sequence Orthology more info
involved_in pentose-phosphate shunt, non-oxidative branch	IBA Inferred from Biological aspect of Ancestor more info
involved_in pentose-phosphate shunt, non-oxidative branch	IDA Inferred from Direct Assay more info	PubMed
involved_in pentose-phosphate shunt, non-oxidative branch	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ribose-5-phosphate isomerase

NP_001102102.1

EC 5.3.1.6

XP_006236690.1

EC 5.3.1.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108632.1 → NP_001102102.1 ribose-5-phosphate isomerase

See identical proteins and their annotated locations for NP_001102102.1

Status: PROVISIONAL

Source sequence(s)

CH473957

UniProtKB/TrEMBL

A6IA59, D4A7L6

Related

ENSRNOP00000007927.4, ENSRNOT00000007927.7

Conserved Domains (1) summary

cd01398
Location:74 → 291

RPI_A; RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

104282081..104307732 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006236628.5 → XP_006236690.1 ribose-5-phosphate isomerase isoform X1

UniProtKB/TrEMBL

A0A8I6AS52

Related

ENSRNOP00000097607.1, ENSRNOT00000094761.2

Conserved Domains (1) summary

cd01398
Location:74 → 271

RPI_A; RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the ...