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Ggct gamma-glutamyl cyclotransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 362368, updated on 25-Jan-2022

Summary

Official Symbol
Ggctprovided by RGD
Official Full Name
gamma-glutamyl cyclotransferaseprovided by RGD
Primary source
RGD:1304876
See related
Ensembl:ENSRNOG00000034084 AllianceGenome:RGD:1304876
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ggctl1; RGD1304876; RGD1562590
Summary
Predicted to enable gamma-glutamylcyclotransferase activity and protein homodimerization activity. Predicted to be involved in release of cytochrome c from mitochondria. Predicted to be located in cytosol. Orthologous to human GGCT (gamma-glutamylcyclotransferase). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Kidney (RPKM 559.6), Liver (RPKM 114.0) and 7 other tissues See more
Orthologs
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Genomic context

See Ggct in Genome Data Viewer
Location:
4q24
Exon count:
4
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (84122921..84129327, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (85186644..85192857, complement)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene nucleotide-binding oligomerization domain containing 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene 60S ribosomal protein L12-like Neighboring gene uncharacterized LOC102550675

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables gamma-glutamylcyclotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables gamma-glutamylcyclotransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
gamma-glutamylcyclotransferase
Names
gamma-glutamyl cyclotransferase-like 1
NP_001102099.1
XP_038963727.1
XP_038963728.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108629.2NP_001102099.1  gamma-glutamylcyclotransferase

    See identical proteins and their annotated locations for NP_001102099.1

    Status: VALIDATED

    Source sequence(s)
    FM060344, JACYVU010000142
    UniProtKB/TrEMBL
    D3ZPV8
    Related
    ENSRNOP00000049903.3, ENSRNOT00000043752.5
    Conserved Domains (1) summary
    pfam13772
    Location:78160
    AIG2_2; AIG2-like family

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    84122921..84129327 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107799.1XP_038963727.1  gamma-glutamylcyclotransferase isoform X1

    Conserved Domains (1) summary
    pfam13772
    Location:19101
    AIG2_2; AIG2-like family
  2. XM_039107800.1XP_038963728.1  gamma-glutamylcyclotransferase isoform X2

    Conserved Domains (1) summary
    cd06661
    Location:1996
    GGCT_like; GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is ...

RNA

  1. XR_005503254.1 RNA Sequence

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