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Fkbp14 FKBP prolyl isomerase 14 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362366, updated on 5-Jan-2022

Summary

Official Symbol
Fkbp14provided by RGD
Official Full Name
FKBP prolyl isomerase 14provided by RGD
Primary source
RGD:1311705
See related
Ensembl:ENSRNOG00000009886
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium ion binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein peptidyl-prolyl isomerization. Predicted to be located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome kyphoscoliotic type 2. Orthologous to human FKBP14 (FKBP prolyl isomerase 14). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Heart (RPKM 144.7), Lung (RPKM 101.3) and 9 other tissues See more
Orthologs
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Genomic context

See Fkbp14 in Genome Data Viewer
Location:
4q24
Exon count:
6
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (83705531..83721515, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (84753628..84768314, complement)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene WAS/WASL interacting protein family, member 3 Neighboring gene secernin 1 Neighboring gene uncharacterized LOC102553885 Neighboring gene mitochondrial import receptor subunit TOM7 homolog Neighboring gene pleckstrin homology domain containing A8 Neighboring gene maturin, neural progenitor differentiation regulator homolog

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein peptidyl-prolyl isomerization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase FKBP14
Names
FK506 binding protein 14
NP_001013228.1
XP_017448176.1
XP_038963725.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013210.1NP_001013228.1  peptidyl-prolyl cis-trans isomerase FKBP14 precursor

    See identical proteins and their annotated locations for NP_001013228.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083746
    UniProtKB/TrEMBL
    Q5XID8
    Related
    ENSRNOP00000087077.1, ENSRNOT00000119659.1
    Conserved Domains (2) summary
    pfam00254
    Location:38132
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam13499
    Location:141204
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    83705531..83721515 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107797.1XP_038963725.1  peptidyl-prolyl cis-trans isomerase FKBP14 isoform X2

    Related
    ENSRNOP00000013205.5, ENSRNOT00000013205.8
    Conserved Domains (2) summary
    COG0545
    Location:3655
    FkpA; FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones]
    pfam13499
    Location:61124
    EF-hand_7; EF-hand domain pair
  2. XM_017592687.2XP_017448176.1  peptidyl-prolyl cis-trans isomerase FKBP14 isoform X1

    Related
    ENSRNOP00000079630.1, ENSRNOT00000108764.1
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