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Pals2 protein associated with LIN7 2, MAGUK p55 family member [ Rattus norvegicus (Norway rat) ]

Gene ID: 362359, updated on 5-Jan-2022

Summary

Official Symbol
Pals2provided by RGD
Official Full Name
protein associated with LIN7 2, MAGUK p55 family memberprovided by RGD
Primary source
RGD:1311833
See related
Ensembl:ENSRNOG00000021579
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mpp6
Summary
Predicted to be located in plasma membrane. Orthologous to human PALS2 (protein associated with LIN7 2, MAGUK p55 family member). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Liver (RPKM 115.9), Brain (RPKM 100.3) and 9 other tissues See more
Orthologs
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Genomic context

See Pals2 in Genome Data Viewer
Location:
4q24
Exon count:
17
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (79173488..79257542)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (79846506..79928977)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene neuropeptide Y Neighboring gene uncharacterized LOC102555694 Neighboring gene basic proline-rich protein-like Neighboring gene gasdermin E Neighboring gene oxysterol binding protein-like 3 Neighboring gene uncharacterized LOC120102268

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Homology

Clone Names

  • MGC189400

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cellular_component ND
No biological Data available
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
MAGUK p55 subfamily member 6
Names
CH474011:EDL88200
membrane palmitoylated protein 6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
protein associated with LIN7 2, MAGUK family member

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134982.1NP_001128454.1  MAGUK p55 subfamily member 6

    See identical proteins and their annotated locations for NP_001128454.1

    Status: PROVISIONAL

    Source sequence(s)
    BC169025
    UniProtKB/TrEMBL
    B5DFE0
    Related
    ENSRNOP00000037380.5, ENSRNOT00000029332.7
    Conserved Domains (6) summary
    smart00569
    Location:255
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12038
    Location:219279
    SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
    smart00072
    Location:347528
    GuKc; Guanylate kinase homologues
    cd00992
    Location:133206
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:337527
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:57108
    L27; L27 domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    79173488..79257542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107787.1XP_038963715.1  MAGUK p55 subfamily member 6 isoform X1

    Conserved Domains (5) summary
    smart00569
    Location:255
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12038
    Location:233293
    SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
    cd00992
    Location:133206
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:351541
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:57108
    L27; L27 domain
  2. XM_039107784.1XP_038963712.1  MAGUK p55 subfamily member 6 isoform X1

    Conserved Domains (5) summary
    smart00569
    Location:255
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12038
    Location:233293
    SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
    cd00992
    Location:133206
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:351541
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:57108
    L27; L27 domain
  3. XM_006236496.4XP_006236558.1  MAGUK p55 subfamily member 6 isoform X1

    See identical proteins and their annotated locations for XP_006236558.1

    Related
    ENSRNOP00000097400.1, ENSRNOT00000096577.1
    Conserved Domains (5) summary
    smart00569
    Location:255
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12038
    Location:233293
    SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
    cd00992
    Location:133206
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:351541
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:57108
    L27; L27 domain
  4. XM_039107785.1XP_038963713.1  MAGUK p55 subfamily member 6 isoform X1

    Conserved Domains (5) summary
    smart00569
    Location:255
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12038
    Location:233293
    SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
    cd00992
    Location:133206
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:351541
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:57108
    L27; L27 domain
  5. XM_006236497.4XP_006236559.1  MAGUK p55 subfamily member 6 isoform X1

    See identical proteins and their annotated locations for XP_006236559.1

    Conserved Domains (5) summary
    smart00569
    Location:255
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12038
    Location:233293
    SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
    cd00992
    Location:133206
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:351541
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:57108
    L27; L27 domain
  6. XM_039107786.1XP_038963714.1  MAGUK p55 subfamily member 6 isoform X1

    Conserved Domains (5) summary
    smart00569
    Location:255
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12038
    Location:233293
    SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
    cd00992
    Location:133206
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:351541
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:57108
    L27; L27 domain
  7. XM_008762897.3XP_008761119.1  MAGUK p55 subfamily member 6 isoform X1

    See identical proteins and their annotated locations for XP_008761119.1

    Conserved Domains (5) summary
    smart00569
    Location:255
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12038
    Location:233293
    SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
    cd00992
    Location:133206
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:351541
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:57108
    L27; L27 domain
  8. XM_039107788.1XP_038963716.1  MAGUK p55 subfamily member 6 isoform X2

    Conserved Domains (5) summary
    smart00569
    Location:255
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd00992
    Location:133206
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:351498
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:57108
    L27; L27 domain
    cl17036
    Location:233293
    SH3; Src Homology 3 domain superfamily

RNA

  1. XR_005503249.1 RNA Sequence

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