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Creb3l2 cAMP responsive element binding protein 3-like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362339, updated on 10-Jul-2024

Summary

Symbol
Creb3l2provided by RGD
Full Name
cAMP responsive element binding protein 3-like 2provided by RGD
Primary source
RGD:1306040
See related
EnsemblRapid:ENSRNOG00000026705 AllianceGenome:RGD:1306040
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ra69; SCIRR69
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in several processes, including positive regulation of neuron projection development; response to endoplasmic reticulum stress; and response to wounding. Located in chromatin; nucleus; and perinuclear endoplasmic reticulum. Orthologous to human CREB3L2 (cAMP responsive element binding protein 3 like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 145.9), Heart (RPKM 120.0) and 9 other tissues See more
Orthologs
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Genomic context

See Creb3l2 in Genome Data Viewer
Location:
4q22
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (66874623..66990962, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (65907570..66112078, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (64869285..64981519, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene pleiotrophin Neighboring gene diacylglycerol kinase, iota Neighboring gene aldo-keto reductase family 1, member D1 Neighboring gene uncharacterized LOC134486755

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cartilage development ISO
Inferred from Sequence Orthology
more info
 
involved_in cartilage development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in chondrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in chondrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in chondrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 
involved_in response to endoplasmic reticulum stress IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
involved_in response to endoplasmic reticulum stress ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to unfolded protein IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perinuclear endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cyclic AMP-responsive element-binding protein 3-like protein 2
Names
SCI-related protein Ra69
cAMP-responsive element-binding protein 3-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012188.2NP_001012188.1  cyclic AMP-responsive element-binding protein 3-like protein 2

    See identical proteins and their annotated locations for NP_001012188.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q6QDP7
    Related
    ENSRNOP00000017338.6, ENSRNOT00000017338.7
    Conserved Domains (1) summary
    cd14689
    Location:305348
    bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    66874623..66990962 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107780.2XP_038963708.1  cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8L2Q9L4, A6IEQ6
    Related
    ENSRNOP00000103942.1, ENSRNOT00000136798.1
    Conserved Domains (1) summary
    cd14689
    Location:305348
    bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain