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B4galt5 beta-1,4-galactosyltransferase 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362275, updated on 5-Sep-2025
Official Symbol
B4galt5provided by RGD
Official Full Name
beta-1,4-galactosyltransferase 5provided by RGD
Primary source
RGD:1310062
See related
Ensembl:ENSRNOG00000008283 AllianceGenome:RGD:1310062
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable N-acetyllactosamine synthase activity and UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity. Predicted to be involved in several processes, including ganglioside biosynthetic process via lactosylceramide; neurogenesis; and positive regulation of embryonic development. Predicted to act upstream of or within poly-N-acetyllactosamine biosynthetic process. Predicted to be located in Golgi cisterna membrane and Golgi membrane. Predicted to be active in Golgi apparatus. Orthologous to human B4GALT5 (beta-1,4-galactosyltransferase 5). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Adrenal (RPKM 153.8), Lung (RPKM 92.7) and 9 other tissues See more
Orthologs
human mouse all
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See B4galt5 in Genome Data Viewer
Location:
3q42
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (176437073..176453001, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (156018056..156033983, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (164039731..164055561, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene prostaglandin I2 synthase Neighboring gene ribosomal protein L38, pseudogene 9 Neighboring gene uncharacterized LOC120101788 Neighboring gene small nucleolar RNA SNORD22

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Involvement of murine β-1,4-galactosyltransferase V in lactosylceramide biosynthesis. Kumagai T, et al. Glycoconj J, 2010 Oct. PMID 21057870, Free PMC Article
  2. Beta4-galactosyltransferase-5 is a lactosylceramide synthase essential for mouse extra-embryonic development. Nishie T, et al. Glycobiology, 2010 Oct. PMID 20574042
  3. The expression patterns of beta1,4 galactosyltransferase I and V mRNAs, and Galbeta1-4GlcNAc group in rat gastrocnemius muscles post sciatic nerve injury. Yan M, et al. Glycoconj J, 2008 Oct. PMID 18512149
  4. Expression change of beta-1,4 galactosyltransferase I, V mRNAs and Galbeta1,4GlcNAc group in rat sciatic nerve after crush. Yan M, et al. J Mol Histol, 2008 Jun. PMID 18320333
  5. The Immunological Regulation Roles of Porcine β-1, 4 Galactosyltransferase V (B4GALT5) in PRRSV Infection. Zhang L, et al. Front Cell Infect Microbiol, 2018. PMID 29546034, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. beta1,4-GalT I and V might play important roles in the regeneration of the injured sciatic nerve.
    Title: Expression change of beta-1,4 galactosyltransferase I, V mRNAs and Galbeta1,4GlcNAc group in rat sciatic nerve after crush.
  2. These results indicated that the expressions of beta1,4-GalT I, V mRNAs and Galbeta1-4GlcNAc group were involved in the process of denervation and reinnervation.
    Title: The expression patterns of beta1,4 galactosyltransferase I and V mRNAs, and Galbeta1-4GlcNAc group in rat gastrocnemius muscles post sciatic nerve injury.
  3. These results suggest that an autocrine loop involving TNF-alpha, TNFR1 and TNFR2 contributes to the production of beta-1,4-GalT I and V mRNA in response to inflammation.
    Title: The role of TNF-alpha and its receptors in the production of beta-1,4 galactosyltransferase I and V mRNAs by rat primary astrocytes.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N-acetyllactosamine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables N-acetyllactosamine synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in central nervous system myelination IEA
Inferred from Electronic Annotation
more info
  
involved_in central nervous system myelination ISO
Inferred from Sequence Orthology
more info
  
involved_in central nervous system neuron axonogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in central nervous system neuron axonogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in ganglioside biosynthetic process via lactosylceramide IEA
Inferred from Electronic Annotation
more info
  
involved_in ganglioside biosynthetic process via lactosylceramide ISO
Inferred from Sequence Orthology
more info
  
involved_in glycoprotein biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycosphingolipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron maturation IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron maturation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within poly-N-acetyllactosamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within poly-N-acetyllactosamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of embryonic development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein stability IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
  
involved_in sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
beta-1,4-galactosyltransferase 5
Names
UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001438263.1 → NP_001425192.1  beta-1,4-galactosyltransferase 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A0G2K3K5, A6JXJ6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    176437073..176453001 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108608.1: Suppressed sequence

    Description
    NM_001108608.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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